Sc(OTf)3-catalyzed three-component cyclization of arylamines, β,γ-unsaturated α-ketoesters, and 1,3-dicarbonyl compounds for the synthesis of highly substituted 1,4-dihydropyridines and tetrahydropyridines

Lu Liu; Ryan Sarkisian; Yongming Deng; Hong Wang

doi:10.1021/jo400578m

Sc(OTf)₃-catalyzed three-component cyclization of arylamines, β,γ-unsaturated α-ketoesters, and 1,3-dicarbonyl compounds for the synthesis of highly substituted 1,4-dihydropyridines and tetrahydropyridines

Lu Liu
, Ryan Sarkisian
, Yongming Deng
, Hong Wang^*

^*Corresponding author for this work

Miami University

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

A Sc(OTf)₃-catalyzed three-component cyclization reaction of arylamines, β,γ-unsaturated α-ketoesters and 1,3-dicarbonyl compounds was developed to synthesize highly substituted 1,4-dihydropyridines and fused bicyclic tetrahydropyridines carrying a quaternary all-carbon center.

Original language	English
Pages (from-to)	5751-5755
Number of pages	5
Journal	Journal of Organic Chemistry
Volume	78
Issue number	11
DOIs	https://doi.org/10.1021/jo400578m
State	Published - 7 Jun 2013
Externally published	Yes

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@article{a483073b5bf646c3baecb15e51c6a1ab,

title = "Sc(OTf)3-catalyzed three-component cyclization of arylamines, β,γ-unsaturated α-ketoesters, and 1,3-dicarbonyl compounds for the synthesis of highly substituted 1,4-dihydropyridines and tetrahydropyridines",

abstract = "A Sc(OTf)3-catalyzed three-component cyclization reaction of arylamines, β,γ-unsaturated α-ketoesters and 1,3-dicarbonyl compounds was developed to synthesize highly substituted 1,4-dihydropyridines and fused bicyclic tetrahydropyridines carrying a quaternary all-carbon center.",

author = "Lu Liu and Ryan Sarkisian and Yongming Deng and Hong Wang",

year = "2013",

month = jun,

day = "7",

doi = "10.1021/jo400578m",

language = "英语",

volume = "78",

pages = "5751--5755",

journal = "Journal of Organic Chemistry",

issn = "0022-3263",

publisher = "American Chemical Society",

number = "11",

}

Sc(OTf)₃-catalyzed three-component cyclization of arylamines, β,γ-unsaturated α-ketoesters, and 1,3-dicarbonyl compounds for the synthesis of highly substituted 1,4-dihydropyridines and tetrahydropyridines. / Liu, Lu; Sarkisian, Ryan; Deng, Yongming et al.
In: Journal of Organic Chemistry, Vol. 78, No. 11, 07.06.2013, p. 5751-5755.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Sc(OTf)3-catalyzed three-component cyclization of arylamines, β,γ-unsaturated α-ketoesters, and 1,3-dicarbonyl compounds for the synthesis of highly substituted 1,4-dihydropyridines and tetrahydropyridines

AU - Liu, Lu

AU - Sarkisian, Ryan

AU - Deng, Yongming

AU - Wang, Hong

PY - 2013/6/7

Y1 - 2013/6/7

N2 - A Sc(OTf)3-catalyzed three-component cyclization reaction of arylamines, β,γ-unsaturated α-ketoesters and 1,3-dicarbonyl compounds was developed to synthesize highly substituted 1,4-dihydropyridines and fused bicyclic tetrahydropyridines carrying a quaternary all-carbon center.

AB - A Sc(OTf)3-catalyzed three-component cyclization reaction of arylamines, β,γ-unsaturated α-ketoesters and 1,3-dicarbonyl compounds was developed to synthesize highly substituted 1,4-dihydropyridines and fused bicyclic tetrahydropyridines carrying a quaternary all-carbon center.

UR - https://www.scopus.com/pages/publications/84879288206

U2 - 10.1021/jo400578m

DO - 10.1021/jo400578m

M3 - 文章

C2 - 23614840

AN - SCOPUS:84879288206

SN - 0022-3263

VL - 78

SP - 5751

EP - 5755

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 11