Scarring Skin: Mechanisms and Therapies

Xinye Lin; Yuping Lai

doi:10.3390/ijms25031458

Scarring Skin: Mechanisms and Therapies

Xinye Lin
, Yuping Lai^*

^*Corresponding author for this work

School of Life Sciences

East China Normal University

Research output: Contribution to journal › Review article › peer-review

42 Scopus citations

Abstract

Skin injury always results in fibrotic, non-functional scars in adults. Although multiple factors are well-known contributors to scar formation, the precise underlying mechanisms remain elusive. This review aims to elucidate the intricacies of the wound healing process, summarize the known factors driving skin cells in wounds toward a scarring fate, and particularly to discuss the impact of fibroblast heterogeneity on scar formation. To the end, we explore potential therapeutic interventions used in the treatment of scarring wounds.

Original language	English
Article number	1458
Journal	International Journal of Molecular Sciences
Volume	25
Issue number	3
DOIs	https://doi.org/10.3390/ijms25031458
State	Published - Feb 2024

Keywords

fibroblast heterogeneity
scar formation
scar treatments

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10.3390/ijms25031458

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title = "Scarring Skin: Mechanisms and Therapies",

abstract = "Skin injury always results in fibrotic, non-functional scars in adults. Although multiple factors are well-known contributors to scar formation, the precise underlying mechanisms remain elusive. This review aims to elucidate the intricacies of the wound healing process, summarize the known factors driving skin cells in wounds toward a scarring fate, and particularly to discuss the impact of fibroblast heterogeneity on scar formation. To the end, we explore potential therapeutic interventions used in the treatment of scarring wounds.",

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author = "Xinye Lin and Yuping Lai",

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AU - Lin, Xinye

AU - Lai, Yuping

PY - 2024/2

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N2 - Skin injury always results in fibrotic, non-functional scars in adults. Although multiple factors are well-known contributors to scar formation, the precise underlying mechanisms remain elusive. This review aims to elucidate the intricacies of the wound healing process, summarize the known factors driving skin cells in wounds toward a scarring fate, and particularly to discuss the impact of fibroblast heterogeneity on scar formation. To the end, we explore potential therapeutic interventions used in the treatment of scarring wounds.

AB - Skin injury always results in fibrotic, non-functional scars in adults. Although multiple factors are well-known contributors to scar formation, the precise underlying mechanisms remain elusive. This review aims to elucidate the intricacies of the wound healing process, summarize the known factors driving skin cells in wounds toward a scarring fate, and particularly to discuss the impact of fibroblast heterogeneity on scar formation. To the end, we explore potential therapeutic interventions used in the treatment of scarring wounds.

KW - fibroblast heterogeneity

KW - scar formation

KW - scar treatments

UR - https://www.scopus.com/pages/publications/85184496276

U2 - 10.3390/ijms25031458

DO - 10.3390/ijms25031458

M3 - 文献综述

C2 - 38338767

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VL - 25

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

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Scarring Skin: Mechanisms and Therapies

Abstract

Keywords

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