Scandium-catalyzed tandem selective oxirane ring-opening/Friedel-Crafts alkylation: A facile access to [1,4]oxazino[4,3-a]indoles and 3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazines

Lai Wei; Lu Liu; Junliang Zhang

doi:10.1039/c4ob01057d

Scandium-catalyzed tandem selective oxirane ring-opening/Friedel-Crafts alkylation: A facile access to [1,4]oxazino[4,3-a]indoles and 3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazines

Lai Wei
, Lu Liu^*
, Junliang Zhang

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China Normal University
CAS - Shanghai Institute of Organic Chemistry

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

A facile technique involving a novel Lewis-acid-catalyzed tandem selective ring-opening of oxirane and Friedel-Crafts alkylation of 1H-indol-1-yl derived oxiranes was developed. The developed protocol affords functionalized [1,4]oxazino[4,3-a]indoles and 3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazines in up to 95% yield. This journal is

Original language	English
Pages (from-to)	6869-6877
Number of pages	9
Journal	Organic and Biomolecular Chemistry
Volume	12
Issue number	35
DOIs	https://doi.org/10.1039/c4ob01057d
State	Published - 21 Sep 2014

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AU - Wei, Lai

AU - Liu, Lu

AU - Zhang, Junliang

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Y1 - 2014/9/21

N2 - A facile technique involving a novel Lewis-acid-catalyzed tandem selective ring-opening of oxirane and Friedel-Crafts alkylation of 1H-indol-1-yl derived oxiranes was developed. The developed protocol affords functionalized [1,4]oxazino[4,3-a]indoles and 3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazines in up to 95% yield. This journal is

AB - A facile technique involving a novel Lewis-acid-catalyzed tandem selective ring-opening of oxirane and Friedel-Crafts alkylation of 1H-indol-1-yl derived oxiranes was developed. The developed protocol affords functionalized [1,4]oxazino[4,3-a]indoles and 3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazines in up to 95% yield. This journal is

UR - https://www.scopus.com/pages/publications/84906233885

U2 - 10.1039/c4ob01057d

DO - 10.1039/c4ob01057d

M3 - 文章

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ER -

Scandium-catalyzed tandem selective oxirane ring-opening/Friedel-Crafts alkylation: A facile access to [1,4]oxazino[4,3-a]indoles and 3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazines

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