Scandium-catalyzed tandem selective oxirane ring-opening/Friedel-Crafts alkylation: A facile access to [1,4]oxazino[4,3-a]indoles and 3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazines

  • Lai Wei
  • , Lu Liu*
  • , Junliang Zhang
  • *Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

A facile technique involving a novel Lewis-acid-catalyzed tandem selective ring-opening of oxirane and Friedel-Crafts alkylation of 1H-indol-1-yl derived oxiranes was developed. The developed protocol affords functionalized [1,4]oxazino[4,3-a]indoles and 3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazines in up to 95% yield. This journal is

Original languageEnglish
Pages (from-to)6869-6877
Number of pages9
JournalOrganic and Biomolecular Chemistry
Volume12
Issue number35
DOIs
StatePublished - 21 Sep 2014

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