Role of Autophagy Inhibition in Regulating Hepatic Lipid Metabolism: Molecular Cross Talk Between Proteasome Activator REGγ and SirT1 Signaling

With an increase in the metabolic disorders, there is a growing need to further understand the mechanisms of lipid metabolism. Recent studies have identified that two major proteolytic degradative pathways-autophagy and proteasome-are mutually regulated and play a critical role in modulating cellular lipid homeostasis. Linking these two pathways is the REGγ-SirT1 complex, and different energy contexts can affect the interactions between these two proteins, which further influences the autophagy activity and lipid metabolism. The recent study highlights the potential of the REGγ-SirT1-autophagy pathway as the alternative and promising therapeutic target for the treatment of metabolic disorders like type 2 diabetes, obesity, and liver steatosis.