Ring-restricted N-nitrosated rhodamine as a green-light triggered, orange-emission calibrated and fast-releasing nitric oxide donor

Haihong He; Tingting He; Ziqian Zhang; Xiu Xu; Huibin Yang; Xuhong Qian; Youjun Yang

doi:10.1016/j.cclet.2018.08.019

Ring-restricted N-nitrosated rhodamine as a green-light triggered, orange-emission calibrated and fast-releasing nitric oxide donor

Haihong He, Tingting He, Ziqian Zhang, Xiu Xu, Huibin Yang, Xuhong Qian, Youjun Yang

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Nitric oxide (NO) donors are versatile tools for nitric oxide biology. The biological response of NO is dependent on the transient concentration and the sustained duration. N-Nitrosated rhodamines are photo-triggered and photo-calibrated NO donors. We recently discovered that suppression of the dihedral angle between the N-nitroso fragment with the rhodamine scaffold facilitates NO release. Inspired by this discovery, we developed a fast-releasing NO donor (NOD575) suitable for biological applications, e.g., the pulmonary arterial smooth muscle cells (PASMCs).

Original language	English
Pages (from-to)	1497-1499
Number of pages	3
Journal	Chinese Chemical Letters
Volume	29
Issue number	10
DOIs	https://doi.org/10.1016/j.cclet.2018.08.019
State	Published - Oct 2018
Externally published	Yes

Keywords

Antimicrobial
NO donor
Photo-calibrate
Photo-trigger
Platelet aggregation inhibition

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10.1016/j.cclet.2018.08.019

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title = "Ring-restricted N-nitrosated rhodamine as a green-light triggered, orange-emission calibrated and fast-releasing nitric oxide donor",

abstract = "Nitric oxide (NO) donors are versatile tools for nitric oxide biology. The biological response of NO is dependent on the transient concentration and the sustained duration. N-Nitrosated rhodamines are photo-triggered and photo-calibrated NO donors. We recently discovered that suppression of the dihedral angle between the N-nitroso fragment with the rhodamine scaffold facilitates NO release. Inspired by this discovery, we developed a fast-releasing NO donor (NOD575) suitable for biological applications, e.g., the pulmonary arterial smooth muscle cells (PASMCs).",

keywords = "Antimicrobial, NO donor, Photo-calibrate, Photo-trigger, Platelet aggregation inhibition",

author = "Haihong He and Tingting He and Ziqian Zhang and Xiu Xu and Huibin Yang and Xuhong Qian and Youjun Yang",

note = "Publisher Copyright: {\textcopyright} 2018 The Author",

year = "2018",

month = oct,

doi = "10.1016/j.cclet.2018.08.019",

language = "英语",

volume = "29",

pages = "1497--1499",

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issn = "1001-8417",

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T1 - Ring-restricted N-nitrosated rhodamine as a green-light triggered, orange-emission calibrated and fast-releasing nitric oxide donor

AU - He, Haihong

AU - He, Tingting

AU - Zhang, Ziqian

AU - Xu, Xiu

AU - Yang, Huibin

AU - Qian, Xuhong

AU - Yang, Youjun

PY - 2018/10

Y1 - 2018/10

N2 - Nitric oxide (NO) donors are versatile tools for nitric oxide biology. The biological response of NO is dependent on the transient concentration and the sustained duration. N-Nitrosated rhodamines are photo-triggered and photo-calibrated NO donors. We recently discovered that suppression of the dihedral angle between the N-nitroso fragment with the rhodamine scaffold facilitates NO release. Inspired by this discovery, we developed a fast-releasing NO donor (NOD575) suitable for biological applications, e.g., the pulmonary arterial smooth muscle cells (PASMCs).

AB - Nitric oxide (NO) donors are versatile tools for nitric oxide biology. The biological response of NO is dependent on the transient concentration and the sustained duration. N-Nitrosated rhodamines are photo-triggered and photo-calibrated NO donors. We recently discovered that suppression of the dihedral angle between the N-nitroso fragment with the rhodamine scaffold facilitates NO release. Inspired by this discovery, we developed a fast-releasing NO donor (NOD575) suitable for biological applications, e.g., the pulmonary arterial smooth muscle cells (PASMCs).

KW - Antimicrobial

KW - NO donor

KW - Photo-calibrate

KW - Photo-trigger

KW - Platelet aggregation inhibition

UR - https://www.scopus.com/pages/publications/85053107155

U2 - 10.1016/j.cclet.2018.08.019

DO - 10.1016/j.cclet.2018.08.019

M3 - 文章

AN - SCOPUS:85053107155

SN - 1001-8417

VL - 29

SP - 1497

EP - 1499

JO - Chinese Chemical Letters

JF - Chinese Chemical Letters

IS - 10

ER -

Ring-restricted N-nitrosated rhodamine as a green-light triggered, orange-emission calibrated and fast-releasing nitric oxide donor

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Keywords

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