Rh(iii)-Catalyzed regioselective C-H [4 + 2]: C -annulation of vinyl enaminones with alkynes to form polysubstituted salicylaldehydes

Yinsong Zhao; Qinze Zheng; Chuangui Yu; Zheng Liu; Deping Wang; Jingsong You; Ge Gao

doi:10.1039/c8qo00759d

Rh(iii)-Catalyzed regioselective C-H [4 + 2]: C -annulation of vinyl enaminones with alkynes to form polysubstituted salicylaldehydes

Yinsong Zhao
, Qinze Zheng
, Chuangui Yu
, Zheng Liu
, Deping Wang
, Jingsong You
, Ge Gao^*

^*Corresponding author for this work

Sichuan University

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

A Rh(iii)-catalyzed regioselective C-H [4 + 2] C-annulation reaction of vinyl enaminones with alkynes is developed to provide sterically congested polysubstituted salicylaldehydes. This reaction shows relatively broad substrate scope with good functional group tolerance. The applications of this method to prepare useful synthetic precursors and bioactive skeletons are also exemplified.

Original language	English
Pages (from-to)	2875-2879
Number of pages	5
Journal	Organic Chemistry Frontiers
Volume	5
Issue number	19
DOIs	https://doi.org/10.1039/c8qo00759d
State	Published - 7 Oct 2018
Externally published	Yes

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title = "Rh(iii)-Catalyzed regioselective C-H [4 + 2]: C -annulation of vinyl enaminones with alkynes to form polysubstituted salicylaldehydes",

abstract = "A Rh(iii)-catalyzed regioselective C-H [4 + 2] C-annulation reaction of vinyl enaminones with alkynes is developed to provide sterically congested polysubstituted salicylaldehydes. This reaction shows relatively broad substrate scope with good functional group tolerance. The applications of this method to prepare useful synthetic precursors and bioactive skeletons are also exemplified.",

author = "Yinsong Zhao and Qinze Zheng and Chuangui Yu and Zheng Liu and Deping Wang and Jingsong You and Ge Gao",

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T1 - Rh(iii)-Catalyzed regioselective C-H [4 + 2]

T2 - C -annulation of vinyl enaminones with alkynes to form polysubstituted salicylaldehydes

AU - Zhao, Yinsong

AU - Zheng, Qinze

AU - Yu, Chuangui

AU - Liu, Zheng

AU - Wang, Deping

AU - You, Jingsong

AU - Gao, Ge

PY - 2018/10/7

Y1 - 2018/10/7

N2 - A Rh(iii)-catalyzed regioselective C-H [4 + 2] C-annulation reaction of vinyl enaminones with alkynes is developed to provide sterically congested polysubstituted salicylaldehydes. This reaction shows relatively broad substrate scope with good functional group tolerance. The applications of this method to prepare useful synthetic precursors and bioactive skeletons are also exemplified.

AB - A Rh(iii)-catalyzed regioselective C-H [4 + 2] C-annulation reaction of vinyl enaminones with alkynes is developed to provide sterically congested polysubstituted salicylaldehydes. This reaction shows relatively broad substrate scope with good functional group tolerance. The applications of this method to prepare useful synthetic precursors and bioactive skeletons are also exemplified.

UR - https://www.scopus.com/pages/publications/85053908047

U2 - 10.1039/c8qo00759d

DO - 10.1039/c8qo00759d

M3 - 文章

AN - SCOPUS:85053908047

SN - 2052-4110

VL - 5

SP - 2875

EP - 2879

JO - Organic Chemistry Frontiers

JF - Organic Chemistry Frontiers

IS - 19

ER -

Rh(iii)-Catalyzed regioselective C-H [4 + 2]: C -annulation of vinyl enaminones with alkynes to form polysubstituted salicylaldehydes

Abstract

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