Rh(II)-Catalyzed Tandem Reaction of 2-Trimethylsiloxy-pyridine and α-Trifluoromethyl Diazomethane: An Approach to Tetrasubstituted gem-Difluoro Olefins

Guang Hui Li; Xin Yu Huang; Jun Xi Lv; Xue Di Zhao; Shengchao Yang; Lu Liu

doi:10.1002/ejoc.202400899

Rh(II)-Catalyzed Tandem Reaction of 2-Trimethylsiloxy-pyridine and α-Trifluoromethyl Diazomethane: An Approach to Tetrasubstituted gem-Difluoro Olefins

Guang Hui Li, Xin Yu Huang, Jun Xi Lv, Xue Di Zhao, Shengchao Yang, Lu Liu

School of Chemistry and Molecular Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

Herein, we describe a Rh₂(OAc)₄-catalyzed reaction of 2-trimethylsiloxy-pyridine and fluorinated diazomethanes, which provides an effective and straightforward approach to the synthesis of 2-oxopyridinyl tetrasubstituted gem-difluoro olefins. This protocol features good functional group compatibility, mild reaction conditions, good yield, and readily available substrates.

Original language	English
Article number	e202400899
Journal	European Journal of Organic Chemistry
Volume	27
Issue number	48
DOIs	https://doi.org/10.1002/ejoc.202400899
State	Published - 23 Dec 2024

Keywords

2-oxopyridinyl
2-trimethylsiloxy-pyridine
gem-difluoro olefin
rhodium-catalyzed
trifluoromethyl carbene

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10.1002/ejoc.202400899

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title = "Rh(II)-Catalyzed Tandem Reaction of 2-Trimethylsiloxy-pyridine and α-Trifluoromethyl Diazomethane: An Approach to Tetrasubstituted gem-Difluoro Olefins",

abstract = "Herein, we describe a Rh2(OAc)4-catalyzed reaction of 2-trimethylsiloxy-pyridine and fluorinated diazomethanes, which provides an effective and straightforward approach to the synthesis of 2-oxopyridinyl tetrasubstituted gem-difluoro olefins. This protocol features good functional group compatibility, mild reaction conditions, good yield, and readily available substrates.",

keywords = "2-oxopyridinyl, 2-trimethylsiloxy-pyridine, gem-difluoro olefin, rhodium-catalyzed, trifluoromethyl carbene",

author = "Li, \{Guang Hui\} and Huang, \{Xin Yu\} and Lv, \{Jun Xi\} and Zhao, \{Xue Di\} and Shengchao Yang and Lu Liu",

note = "Publisher Copyright: {\textcopyright} 2024 Wiley-VCH GmbH.",

year = "2024",

month = dec,

day = "23",

doi = "10.1002/ejoc.202400899",

language = "英语",

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journal = "European Journal of Organic Chemistry",

issn = "1434-193X",

publisher = "Wiley-VCH Verlag",

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TY - JOUR

T1 - Rh(II)-Catalyzed Tandem Reaction of 2-Trimethylsiloxy-pyridine and α-Trifluoromethyl Diazomethane

T2 - An Approach to Tetrasubstituted gem-Difluoro Olefins

AU - Li, Guang Hui

AU - Huang, Xin Yu

AU - Lv, Jun Xi

AU - Zhao, Xue Di

AU - Yang, Shengchao

AU - Liu, Lu

PY - 2024/12/23

Y1 - 2024/12/23

N2 - Herein, we describe a Rh2(OAc)4-catalyzed reaction of 2-trimethylsiloxy-pyridine and fluorinated diazomethanes, which provides an effective and straightforward approach to the synthesis of 2-oxopyridinyl tetrasubstituted gem-difluoro olefins. This protocol features good functional group compatibility, mild reaction conditions, good yield, and readily available substrates.

AB - Herein, we describe a Rh2(OAc)4-catalyzed reaction of 2-trimethylsiloxy-pyridine and fluorinated diazomethanes, which provides an effective and straightforward approach to the synthesis of 2-oxopyridinyl tetrasubstituted gem-difluoro olefins. This protocol features good functional group compatibility, mild reaction conditions, good yield, and readily available substrates.

KW - 2-oxopyridinyl

KW - 2-trimethylsiloxy-pyridine

KW - gem-difluoro olefin

KW - rhodium-catalyzed

KW - trifluoromethyl carbene

UR - https://www.scopus.com/pages/publications/85211205238

U2 - 10.1002/ejoc.202400899

DO - 10.1002/ejoc.202400899

M3 - 文章

AN - SCOPUS:85211205238

SN - 1434-193X

VL - 27

JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

IS - 48

M1 - e202400899

ER -

Rh(II)-Catalyzed Tandem Reaction of 2-Trimethylsiloxy-pyridine and α-Trifluoromethyl Diazomethane: An Approach to Tetrasubstituted gem-Difluoro Olefins

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Keywords

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