Response to Comment on "Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence"

Zhiqiang Ma; Xiaolei Wang; Xiao Wang; Rodrigo A. Rodriguez; Curtis E. Moore; Shuanhu Gao; Xianghui Tan; Yuyong Ma; Arnold L. Rheingold; Phil S. Baran; Chuo Chen

doi:10.1126/science.aaa9626

Response to Comment on "Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence"

Zhiqiang Ma
, Xiaolei Wang
, Xiao Wang
, Rodrigo A. Rodriguez
, Curtis E. Moore
, Shuanhu Gao
, Xianghui Tan
, Yuyong Ma
, Arnold L. Rheingold
, Phil S. Baran
, Chuo Chen^*

^*Corresponding author for this work

Research output: Contribution to journal › Comment/debate

7 Scopus citations

Abstract

Sherman et al. commented on the precedence of enantiodivergence, listing a number of congeneric natural products with opposite chirality. However, these "congeners" are not derived from enantiodivergent biosyntheses. Instead, they are antipodes arising from separate enantiomeric biosyntheses. A distinct feature of the biosynthesis of the cyclic pyrrole-imidazole dimers is the production of antipodal congeners without the corresponding enantiomers.

Original language	English
Pages (from-to)	149c
Journal	Science
Volume	349
Issue number	6244
DOIs	https://doi.org/10.1126/science.aaa9626
State	Published - 10 Jul 2015
Externally published	Yes

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10.1126/science.aaa9626

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title = "Response to Comment on {"}Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence{"}",

abstract = "Sherman et al. commented on the precedence of enantiodivergence, listing a number of congeneric natural products with opposite chirality. However, these {"}congeners{"} are not derived from enantiodivergent biosyntheses. Instead, they are antipodes arising from separate enantiomeric biosyntheses. A distinct feature of the biosynthesis of the cyclic pyrrole-imidazole dimers is the production of antipodal congeners without the corresponding enantiomers.",

author = "Zhiqiang Ma and Xiaolei Wang and Xiao Wang and Rodriguez, \{Rodrigo A.\} and Moore, \{Curtis E.\} and Shuanhu Gao and Xianghui Tan and Yuyong Ma and Rheingold, \{Arnold L.\} and Baran, \{Phil S.\} and Chuo Chen",

year = "2015",

month = jul,

day = "10",

doi = "10.1126/science.aaa9626",

language = "英语",

volume = "349",

pages = "149c",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "6244",

}

TY - JOUR

T1 - Response to Comment on "Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence"

AU - Ma, Zhiqiang

AU - Wang, Xiaolei

AU - Wang, Xiao

AU - Rodriguez, Rodrigo A.

AU - Moore, Curtis E.

AU - Gao, Shuanhu

AU - Tan, Xianghui

AU - Ma, Yuyong

AU - Rheingold, Arnold L.

AU - Baran, Phil S.

AU - Chen, Chuo

PY - 2015/7/10

Y1 - 2015/7/10

N2 - Sherman et al. commented on the precedence of enantiodivergence, listing a number of congeneric natural products with opposite chirality. However, these "congeners" are not derived from enantiodivergent biosyntheses. Instead, they are antipodes arising from separate enantiomeric biosyntheses. A distinct feature of the biosynthesis of the cyclic pyrrole-imidazole dimers is the production of antipodal congeners without the corresponding enantiomers.

AB - Sherman et al. commented on the precedence of enantiodivergence, listing a number of congeneric natural products with opposite chirality. However, these "congeners" are not derived from enantiodivergent biosyntheses. Instead, they are antipodes arising from separate enantiomeric biosyntheses. A distinct feature of the biosynthesis of the cyclic pyrrole-imidazole dimers is the production of antipodal congeners without the corresponding enantiomers.

UR - https://www.scopus.com/pages/publications/84937566050

U2 - 10.1126/science.aaa9626

DO - 10.1126/science.aaa9626

M3 - 评论/辩论

C2 - 26160939

AN - SCOPUS:84937566050

SN - 0036-8075

VL - 349

SP - 149c

JO - Science

JF - Science

IS - 6244

ER -

Response to Comment on "Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence"

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