Abstract
-Chymotrypsin immobilized on super paramagnetic nanogels covered with carboxyl groups, exhibited high stereoselectivity in kinetic resolution of racemic phenylalanine in toluene/water biphasic system, and even improved reusability over its parent free enzyme. The results also showed that the addition of ionic liquid to water phase could enhance the stereoselectivity of the immobilized enzyme to a certain extent while the conversion yield decreased. The long-term stability allows the supported enzyme with nano-scaled dimension to use in continuous chiral resolution reaction, which opens a new horizon for enzymatic chiral resolution in large-scale production.
| Original language | English |
|---|---|
| Pages (from-to) | 943-948 |
| Number of pages | 6 |
| Journal | Journal of Macromolecular Science, Part A: Pure and Applied Chemistry |
| Volume | 46 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 2009 |
Keywords
- (DL)-Phenylalanine
- Enzymic resolution
- Immobilized -chymotrypsinc
- Ionic liquid
- Superparamagnetic nanogels
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