Research on optimal scheduling model of antibiotics fermentation process

The antibiotics multi-reactor fermentation process with parallel lines is analyzed. The allocation of tasks, units and events is described by two sets of binary variables. Based on continuous time representation, a mixed integer linear programming (MILP) model for antibiotics multi-reactor fermentation process with parallel lines is built. The scheduling model has few binary variables and can be solved quickly. The optimal solution also gives the shortest production time and the optimal sequence of batches. The computational example of cephalosporin fermentation process demonstrates the feasibility and validity of the scheduling model.