Regulation of KiSS1 gene expression

Dali Li; Weishi Yu; Mingyao Liu

doi:10.1016/j.peptides.2008.09.025

Regulation of KiSS1 gene expression

Dali Li, Weishi Yu, Mingyao Liu

School of Life Sciences

Research output: Contribution to journal › Review article › peer-review

21 Scopus citations

Abstract

Kisspeptins are the protein products encoded by KiSS1 gene, an important tumor metastatic suppressor and pivotal master hormone of puberty. Although KiSS1 gene is expressed in both central and peripheral tissues, the molecular mechanisms that determine the temporal and spatial expression of KiSS1 gene are not well understood. This review provides an update on the latest studies and ideas about the expression of KiSS1 gene as a puberty gatekeeper and a metastasis suppressor, with special emphasis on the molecular mechanisms for the transcriptional regulation of KiSS1 gene expression.

Original language	English
Pages (from-to)	130-138
Number of pages	9
Journal	Peptides
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/j.peptides.2008.09.025
State	Published - Jan 2009

Keywords

Expression
GPR54
KiSS1
Transcriptional regulation

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10.1016/j.peptides.2008.09.025

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title = "Regulation of KiSS1 gene expression",

abstract = "Kisspeptins are the protein products encoded by KiSS1 gene, an important tumor metastatic suppressor and pivotal master hormone of puberty. Although KiSS1 gene is expressed in both central and peripheral tissues, the molecular mechanisms that determine the temporal and spatial expression of KiSS1 gene are not well understood. This review provides an update on the latest studies and ideas about the expression of KiSS1 gene as a puberty gatekeeper and a metastasis suppressor, with special emphasis on the molecular mechanisms for the transcriptional regulation of KiSS1 gene expression.",

keywords = "Expression, GPR54, KiSS1, Transcriptional regulation",

author = "Dali Li and Weishi Yu and Mingyao Liu",

year = "2009",

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AU - Li, Dali

AU - Yu, Weishi

AU - Liu, Mingyao

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N2 - Kisspeptins are the protein products encoded by KiSS1 gene, an important tumor metastatic suppressor and pivotal master hormone of puberty. Although KiSS1 gene is expressed in both central and peripheral tissues, the molecular mechanisms that determine the temporal and spatial expression of KiSS1 gene are not well understood. This review provides an update on the latest studies and ideas about the expression of KiSS1 gene as a puberty gatekeeper and a metastasis suppressor, with special emphasis on the molecular mechanisms for the transcriptional regulation of KiSS1 gene expression.

AB - Kisspeptins are the protein products encoded by KiSS1 gene, an important tumor metastatic suppressor and pivotal master hormone of puberty. Although KiSS1 gene is expressed in both central and peripheral tissues, the molecular mechanisms that determine the temporal and spatial expression of KiSS1 gene are not well understood. This review provides an update on the latest studies and ideas about the expression of KiSS1 gene as a puberty gatekeeper and a metastasis suppressor, with special emphasis on the molecular mechanisms for the transcriptional regulation of KiSS1 gene expression.

KW - Expression

KW - GPR54

KW - KiSS1

KW - Transcriptional regulation

UR - https://www.scopus.com/pages/publications/57849113331

U2 - 10.1016/j.peptides.2008.09.025

DO - 10.1016/j.peptides.2008.09.025

M3 - 文献综述

C2 - 18996159

AN - SCOPUS:57849113331

SN - 0196-9781

VL - 30

SP - 130

EP - 138

JO - Peptides

JF - Peptides

IS - 1

ER -

Regulation of KiSS1 gene expression

Abstract

Keywords

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