Abstract
Nitroaromatic compounds were reductively metabolized to the corresponding amine compounds via the intermediate hydroxylamines by liver microsomes from pig, rat, chook, cattle, sheep, paralichthys olivaceus and cyprinoid in varied reactivity. Similar with baker's yeast, the pig, rat and sheep liver microsomes exhibited high reactivity toward 4-nitro-1,2-dicyanbenzen(1a), while the cyprinoid liver microsomes were inefficient. Contrasted to compound 1a, monocyannitrobenzene(2a) was difficult to reduce by pig liver microsomes. In opposition to grape cells, pig liver microsomes exhibited activities toward some aromatic hydroxylamine compounds.
| Original language | English |
|---|---|
| Pages (from-to) | 981-985 |
| Number of pages | 5 |
| Journal | Chemical Research in Chinese Universities |
| Volume | 26 |
| Issue number | 6 |
| State | Published - 2010 |
| Externally published | Yes |
Keywords
- Aromatic hydroxylamine
- Liver microsome
- Nitroaromatic compound
- Reduction