Recycle waste salt as reagent: A one-pot substitution/Krapcho reaction sequence to -fluorinated esters and sulfones

Feng Zhu; Peng Wei Xu; Feng Zhou; Cui Hong Wang; Jian Zhou

doi:10.1021/acs.orglett.5b00072

Recycle waste salt as reagent: A one-pot substitution/Krapcho reaction sequence to -fluorinated esters and sulfones

Feng Zhu
, Peng Wei Xu
, Feng Zhou
, Cui Hong Wang^*
, Jian Zhou

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

A "one-pot"tandem substitution/Krapcho reaction is reported for the facile synthesis of α-fluorinated esters and sulfones, which utilizes the byproduct salt formed in the substitution step as an indispensible reagent to facilitate the Krapcho reaction step. This represents the first sustainable tandem reaction that internally recycles the waste salt formed in the upstream step as the reagent for the downstream step.

Original language	English
Pages (from-to)	972-975
Number of pages	4
Journal	Organic Letters
Volume	17
Issue number	4
DOIs	https://doi.org/10.1021/acs.orglett.5b00072
State	Published - 20 Feb 2015

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10.1021/acs.orglett.5b00072

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abstract = "A {"}one-pot{"}tandem substitution/Krapcho reaction is reported for the facile synthesis of α-fluorinated esters and sulfones, which utilizes the byproduct salt formed in the substitution step as an indispensible reagent to facilitate the Krapcho reaction step. This represents the first sustainable tandem reaction that internally recycles the waste salt formed in the upstream step as the reagent for the downstream step.",

author = "Feng Zhu and Xu, \{Peng Wei\} and Feng Zhou and Wang, \{Cui Hong\} and Jian Zhou",

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T2 - A one-pot substitution/Krapcho reaction sequence to -fluorinated esters and sulfones

AU - Zhu, Feng

AU - Xu, Peng Wei

AU - Zhou, Feng

AU - Wang, Cui Hong

AU - Zhou, Jian

PY - 2015/2/20

Y1 - 2015/2/20

N2 - A "one-pot"tandem substitution/Krapcho reaction is reported for the facile synthesis of α-fluorinated esters and sulfones, which utilizes the byproduct salt formed in the substitution step as an indispensible reagent to facilitate the Krapcho reaction step. This represents the first sustainable tandem reaction that internally recycles the waste salt formed in the upstream step as the reagent for the downstream step.

AB - A "one-pot"tandem substitution/Krapcho reaction is reported for the facile synthesis of α-fluorinated esters and sulfones, which utilizes the byproduct salt formed in the substitution step as an indispensible reagent to facilitate the Krapcho reaction step. This represents the first sustainable tandem reaction that internally recycles the waste salt formed in the upstream step as the reagent for the downstream step.

UR - https://www.scopus.com/pages/publications/84923325017

U2 - 10.1021/acs.orglett.5b00072

DO - 10.1021/acs.orglett.5b00072

M3 - 文章

AN - SCOPUS:84923325017

SN - 1523-7060

VL - 17

SP - 972

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JO - Organic Letters

JF - Organic Letters

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Recycle waste salt as reagent: A one-pot substitution/Krapcho reaction sequence to -fluorinated esters and sulfones

Abstract

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