Reconfigurable three-dimensional DNA nanostructures for the construction of intracellular logic sensors

Hao Pei; Le Liang; Guangbao Yao; Jiang Li; Qing Huang; Chunhai Fan

doi:10.1002/anie.201202356

Reconfigurable three-dimensional DNA nanostructures for the construction of intracellular logic sensors

Hao Pei, Le Liang, Guangbao Yao, Jiang Li, Qing Huang, Chunhai Fan

Chinese Academy of Sciences

Research output: Contribution to journal › Article › peer-review

376 Scopus citations

Abstract

Right out of the (logic) gate: Logic gates made from 3D DNA nanotetrahedra were constructed that are responsive to various ions, small molecules, and short strands of DNA. By including dynamic sequences in one or more edges of the tetrahedra, a FRET signal can be generated in the manner of AND, OR, XOR, and INH logic gates, as well as a half-adder circuit (see scheme). These DNA logic gates were also applied to intracellular detection of ATP.

Original language	English
Pages (from-to)	9020-9024
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	36
DOIs	https://doi.org/10.1002/anie.201202356
State	Published - 3 Sep 2012
Externally published	Yes

Keywords

DNA computing
DNA structures
biosensors
logic gates

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10.1002/anie.201202356

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abstract = "Right out of the (logic) gate: Logic gates made from 3D DNA nanotetrahedra were constructed that are responsive to various ions, small molecules, and short strands of DNA. By including dynamic sequences in one or more edges of the tetrahedra, a FRET signal can be generated in the manner of AND, OR, XOR, and INH logic gates, as well as a half-adder circuit (see scheme). These DNA logic gates were also applied to intracellular detection of ATP.",

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AU - Pei, Hao

AU - Liang, Le

AU - Yao, Guangbao

AU - Li, Jiang

AU - Huang, Qing

AU - Fan, Chunhai

PY - 2012/9/3

Y1 - 2012/9/3

N2 - Right out of the (logic) gate: Logic gates made from 3D DNA nanotetrahedra were constructed that are responsive to various ions, small molecules, and short strands of DNA. By including dynamic sequences in one or more edges of the tetrahedra, a FRET signal can be generated in the manner of AND, OR, XOR, and INH logic gates, as well as a half-adder circuit (see scheme). These DNA logic gates were also applied to intracellular detection of ATP.

AB - Right out of the (logic) gate: Logic gates made from 3D DNA nanotetrahedra were constructed that are responsive to various ions, small molecules, and short strands of DNA. By including dynamic sequences in one or more edges of the tetrahedra, a FRET signal can be generated in the manner of AND, OR, XOR, and INH logic gates, as well as a half-adder circuit (see scheme). These DNA logic gates were also applied to intracellular detection of ATP.

KW - DNA computing

KW - DNA structures

KW - biosensors

KW - logic gates

UR - https://www.scopus.com/pages/publications/84865857280

U2 - 10.1002/anie.201202356

DO - 10.1002/anie.201202356

M3 - 文章

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ER -

Reconfigurable three-dimensional DNA nanostructures for the construction of intracellular logic sensors

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Keywords

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