Reciprocal Roles of Tom7 and OMA1 during Mitochondrial Import and Activation of PINK1

Shiori Sekine; Chunxin Wang; Dionisia P. Sideris; Eric Bunker; Zhe Zhang; Richard J. Youle

doi:10.1016/j.molcel.2019.01.002

Reciprocal Roles of Tom7 and OMA1 during Mitochondrial Import and Activation of PINK1

Shiori Sekine
, Chunxin Wang
, Dionisia P. Sideris
, Eric Bunker
, Zhe Zhang
, Richard J. Youle^*

^*Corresponding author for this work

National Institutes of Health

Research output: Contribution to journal › Article › peer-review

139 Scopus citations

Abstract

PINK1 activation on damaged mitochondria triggering Parkin-mediated mitophagy is achieved by PINK1 import arrest within mitochondria. Sekine et al. show that this process involves competition between two mitochondrial proteins, Tom7 and OMA1, where a specific motif in PINK1 plays an important role, and describe its pathophysiologic relevance in Parkinson's disease.

Original language	English
Pages (from-to)	1028-1043.e5
Journal	Molecular Cell
Volume	73
Issue number	5
DOIs	https://doi.org/10.1016/j.molcel.2019.01.002
State	Published - 7 Mar 2019
Externally published	Yes

Keywords

OMA1
TIM23 complex
TOM complex
mitochondrial protease
mitophagy

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10.1016/j.molcel.2019.01.002

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title = "Reciprocal Roles of Tom7 and OMA1 during Mitochondrial Import and Activation of PINK1",

abstract = "PINK1 activation on damaged mitochondria triggering Parkin-mediated mitophagy is achieved by PINK1 import arrest within mitochondria. Sekine et al. show that this process involves competition between two mitochondrial proteins, Tom7 and OMA1, where a specific motif in PINK1 plays an important role, and describe its pathophysiologic relevance in Parkinson's disease.",

keywords = "OMA1, TIM23 complex, TOM complex, mitochondrial protease, mitophagy",

author = "Shiori Sekine and Chunxin Wang and Sideris, \{Dionisia P.\} and Eric Bunker and Zhe Zhang and Youle, \{Richard J.\}",

note = "Publisher Copyright: {\textcopyright} 2019",

year = "2019",

month = mar,

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doi = "10.1016/j.molcel.2019.01.002",

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T1 - Reciprocal Roles of Tom7 and OMA1 during Mitochondrial Import and Activation of PINK1

AU - Sekine, Shiori

AU - Wang, Chunxin

AU - Sideris, Dionisia P.

AU - Bunker, Eric

AU - Zhang, Zhe

AU - Youle, Richard J.

PY - 2019/3/7

Y1 - 2019/3/7

N2 - PINK1 activation on damaged mitochondria triggering Parkin-mediated mitophagy is achieved by PINK1 import arrest within mitochondria. Sekine et al. show that this process involves competition between two mitochondrial proteins, Tom7 and OMA1, where a specific motif in PINK1 plays an important role, and describe its pathophysiologic relevance in Parkinson's disease.

AB - PINK1 activation on damaged mitochondria triggering Parkin-mediated mitophagy is achieved by PINK1 import arrest within mitochondria. Sekine et al. show that this process involves competition between two mitochondrial proteins, Tom7 and OMA1, where a specific motif in PINK1 plays an important role, and describe its pathophysiologic relevance in Parkinson's disease.

KW - OMA1

KW - TIM23 complex

KW - TOM complex

KW - mitochondrial protease

KW - mitophagy

UR - https://www.scopus.com/pages/publications/85062351161

U2 - 10.1016/j.molcel.2019.01.002

DO - 10.1016/j.molcel.2019.01.002

M3 - 文章

C2 - 30733118

AN - SCOPUS:85062351161

SN - 1097-2765

VL - 73

SP - 1028-1043.e5

JO - Molecular Cell

JF - Molecular Cell

IS - 5

ER -

Reciprocal Roles of Tom7 and OMA1 during Mitochondrial Import and Activation of PINK1

Abstract

Keywords

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