Abstract
Selective C—F bond activation of the trifluoromethyl group is an important approach for the synthesis of gem-difluoro compounds. Given the importance of trifluoromethyl alkenes in synthetic chemistry as well as their diversity in selectivity, the research on selective C—F bond activation of these compounds has received considerable interest. To this end, The research progress is summarized, including nucleophilic addition/defluorination (SN2' type), acid-promoted defluorinative Friedel-Crafts arylation, (formal) ipso-defluorinative functionalization, and transition-metal-catalyzed migratory insertion/ defluorination.
| Translated title of the contribution | 三氟甲基烯烃的选择性 C—F 键活化最新进展 |
|---|---|
| Original language | English |
| Pages (from-to) | 411-425 |
| Number of pages | 15 |
| Journal | Chinese Journal of Organic Chemistry |
| Volume | 43 |
| Issue number | 2 |
| DOIs | |
| State | Published - 25 Feb 2023 |
| Externally published | Yes |
Keywords
- C—F bond activation
- synthetic method
- trifluoromethyl alkene