Rattle-structured multifunctional nanotheranostics for synergetic chemo-/radiotherapy and simultaneous magnetic/luminescent dual-mode imaging

Wenpei Fan; Bo Shen; Wenbo Bu; Feng Chen; Kuaile Zhao; Shengjian Zhang; Liangping Zhou; Weijun Peng; Qingfeng Xiao; Huaiyong Xing; Jianan Liu; Dalong Ni; Qianjun He; Jianlin Shi

doi:10.1021/ja312225b

Rattle-structured multifunctional nanotheranostics for synergetic chemo-/radiotherapy and simultaneous magnetic/luminescent dual-mode imaging

Wenpei Fan
, Bo Shen
, Wenbo Bu^*
, Feng Chen
, Kuaile Zhao
, Shengjian Zhang
, Liangping Zhou
, Weijun Peng
, Qingfeng Xiao
, Huaiyong Xing
, Jianan Liu
, Dalong Ni
, Qianjun He
, Jianlin Shi

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

319 Scopus citations

Abstract

Most hypoxic tumors are insensitive to radiation, which is a major obstacle in the development of conventional radiotherapy for tumor treatment. Some drugs, such as cisplatin (CDDP), have been extensively used both as an anticancer drug and clinically as a radiosensitizer to enhance radiotherapy. Herein, we develop rattle-structured multifunctional up-conversion core/porous silica shell nanotheranostics (UCSNs) for delivering CDDP to tumors for synergetic chemo-/radiotherapy by CDDP radiosensitization and magnetic/luminescent dual-mode imaging. UCSNs had a dynamic light scattering diameter of 79.1 nm and excellent water dispersity and stability. In vitro studies showed that CDDP loaded in UCSNs (UCSNs-CDDP) was more effective than free CDDP as a radiosensitizer. After injection, UCSNs-CDDP also demonstrated unambiguously enhanced radiotherapy efficacy in vivo. Our report aims at presenting a novel strategy in biomedical nanotechnology that allows simultaneous dual-mode imaging and localized therapy via synergetic chemo-/radiotherapy, which may achieve optimized therapeutic efficacy in cancer treatment.

Original language	English
Pages (from-to)	6494-6503
Number of pages	10
Journal	Journal of the American Chemical Society
Volume	135
Issue number	17
DOIs	https://doi.org/10.1021/ja312225b
State	Published - 1 May 2013
Externally published	Yes

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Fan, W., Shen, B., Bu, W., Chen, F., Zhao, K., Zhang, S., Zhou, L., Peng, W., Xiao, Q., Xing, H., Liu, J., Ni, D., He, Q., & Shi, J. (2013). Rattle-structured multifunctional nanotheranostics for synergetic chemo-/radiotherapy and simultaneous magnetic/luminescent dual-mode imaging. Journal of the American Chemical Society, 135(17), 6494-6503. https://doi.org/10.1021/ja312225b

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title = "Rattle-structured multifunctional nanotheranostics for synergetic chemo-/radiotherapy and simultaneous magnetic/luminescent dual-mode imaging",

abstract = "Most hypoxic tumors are insensitive to radiation, which is a major obstacle in the development of conventional radiotherapy for tumor treatment. Some drugs, such as cisplatin (CDDP), have been extensively used both as an anticancer drug and clinically as a radiosensitizer to enhance radiotherapy. Herein, we develop rattle-structured multifunctional up-conversion core/porous silica shell nanotheranostics (UCSNs) for delivering CDDP to tumors for synergetic chemo-/radiotherapy by CDDP radiosensitization and magnetic/luminescent dual-mode imaging. UCSNs had a dynamic light scattering diameter of 79.1 nm and excellent water dispersity and stability. In vitro studies showed that CDDP loaded in UCSNs (UCSNs-CDDP) was more effective than free CDDP as a radiosensitizer. After injection, UCSNs-CDDP also demonstrated unambiguously enhanced radiotherapy efficacy in vivo. Our report aims at presenting a novel strategy in biomedical nanotechnology that allows simultaneous dual-mode imaging and localized therapy via synergetic chemo-/radiotherapy, which may achieve optimized therapeutic efficacy in cancer treatment.",

author = "Wenpei Fan and Bo Shen and Wenbo Bu and Feng Chen and Kuaile Zhao and Shengjian Zhang and Liangping Zhou and Weijun Peng and Qingfeng Xiao and Huaiyong Xing and Jianan Liu and Dalong Ni and Qianjun He and Jianlin Shi",

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Fan, W, Shen, B, Bu, W, Chen, F, Zhao, K, Zhang, S, Zhou, L, Peng, W, Xiao, Q, Xing, H, Liu, J, Ni, D, He, Q & Shi, J 2013, 'Rattle-structured multifunctional nanotheranostics for synergetic chemo-/radiotherapy and simultaneous magnetic/luminescent dual-mode imaging', Journal of the American Chemical Society, vol. 135, no. 17, pp. 6494-6503. https://doi.org/10.1021/ja312225b

TY - JOUR

T1 - Rattle-structured multifunctional nanotheranostics for synergetic chemo-/radiotherapy and simultaneous magnetic/luminescent dual-mode imaging

AU - Fan, Wenpei

AU - Shen, Bo

AU - Bu, Wenbo

AU - Chen, Feng

AU - Zhao, Kuaile

AU - Zhang, Shengjian

AU - Zhou, Liangping

AU - Peng, Weijun

AU - Xiao, Qingfeng

AU - Xing, Huaiyong

AU - Liu, Jianan

AU - Ni, Dalong

AU - He, Qianjun

AU - Shi, Jianlin

PY - 2013/5/1

Y1 - 2013/5/1

N2 - Most hypoxic tumors are insensitive to radiation, which is a major obstacle in the development of conventional radiotherapy for tumor treatment. Some drugs, such as cisplatin (CDDP), have been extensively used both as an anticancer drug and clinically as a radiosensitizer to enhance radiotherapy. Herein, we develop rattle-structured multifunctional up-conversion core/porous silica shell nanotheranostics (UCSNs) for delivering CDDP to tumors for synergetic chemo-/radiotherapy by CDDP radiosensitization and magnetic/luminescent dual-mode imaging. UCSNs had a dynamic light scattering diameter of 79.1 nm and excellent water dispersity and stability. In vitro studies showed that CDDP loaded in UCSNs (UCSNs-CDDP) was more effective than free CDDP as a radiosensitizer. After injection, UCSNs-CDDP also demonstrated unambiguously enhanced radiotherapy efficacy in vivo. Our report aims at presenting a novel strategy in biomedical nanotechnology that allows simultaneous dual-mode imaging and localized therapy via synergetic chemo-/radiotherapy, which may achieve optimized therapeutic efficacy in cancer treatment.

AB - Most hypoxic tumors are insensitive to radiation, which is a major obstacle in the development of conventional radiotherapy for tumor treatment. Some drugs, such as cisplatin (CDDP), have been extensively used both as an anticancer drug and clinically as a radiosensitizer to enhance radiotherapy. Herein, we develop rattle-structured multifunctional up-conversion core/porous silica shell nanotheranostics (UCSNs) for delivering CDDP to tumors for synergetic chemo-/radiotherapy by CDDP radiosensitization and magnetic/luminescent dual-mode imaging. UCSNs had a dynamic light scattering diameter of 79.1 nm and excellent water dispersity and stability. In vitro studies showed that CDDP loaded in UCSNs (UCSNs-CDDP) was more effective than free CDDP as a radiosensitizer. After injection, UCSNs-CDDP also demonstrated unambiguously enhanced radiotherapy efficacy in vivo. Our report aims at presenting a novel strategy in biomedical nanotechnology that allows simultaneous dual-mode imaging and localized therapy via synergetic chemo-/radiotherapy, which may achieve optimized therapeutic efficacy in cancer treatment.

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DO - 10.1021/ja312225b

M3 - 文章

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AN - SCOPUS:84877056423

SN - 0002-7863

VL - 135

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JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 17

ER -

Rattle-structured multifunctional nanotheranostics for synergetic chemo-/radiotherapy and simultaneous magnetic/luminescent dual-mode imaging

Abstract

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