Pterocarpans and triterpenoids from Gueldenstaedtia verna

Chengle Yin; Jinge Zhou; Yiqing Wu; Yue Cao; Tao Wu; Shoude Zhang; Honglin Li; Zhihong Cheng

doi:10.1016/j.fitote.2015.07.021

Pterocarpans and triterpenoids from Gueldenstaedtia verna

Chengle Yin
, Jinge Zhou
, Yiqing Wu
, Yue Cao
, Tao Wu
, Shoude Zhang
, Honglin Li
, Zhihong Cheng^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Two new pterocarpan glycosides (1-2), five new triterpenoids (3-7), and 13 known analogues (14-20) were isolated from the whole plants of Gueldenstaedtia verna. These new compounds (1-7) were elucidated by extensive spectroscopic techniques including 1D (¹H and ¹³C) and 2D NMR experiments (COSY, HSQC, HMBC and NOESY), HR-ESI-MS and chemical methods. The absolute configuration of 1 was established by the optical rotation, the comparison of experimental and calculated electronic circular dichroism (ECD) spectra and an X-ray diffraction analysis. All the isolates were evaluated for their cytotoxicities against four human cancer cell lines and inhibitory activities on LPS-induced NO production in RAW264.7 cells.

Original language	English
Article number	3238
Pages (from-to)	46-54
Number of pages	9
Journal	Fitoterapia
Volume	106
DOIs	https://doi.org/10.1016/j.fitote.2015.07.021
State	Published - 1 Oct 2015
Externally published	Yes

Keywords

Cytotoxic activity
Gueldenstaedtia verna
Inhibition of NO production
Leguminosae
Pterocarpans
Triterpenoids

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.fitote.2015.07.021

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title = "Pterocarpans and triterpenoids from Gueldenstaedtia verna",

abstract = "Two new pterocarpan glycosides (1-2), five new triterpenoids (3-7), and 13 known analogues (14-20) were isolated from the whole plants of Gueldenstaedtia verna. These new compounds (1-7) were elucidated by extensive spectroscopic techniques including 1D (1H and 13C) and 2D NMR experiments (COSY, HSQC, HMBC and NOESY), HR-ESI-MS and chemical methods. The absolute configuration of 1 was established by the optical rotation, the comparison of experimental and calculated electronic circular dichroism (ECD) spectra and an X-ray diffraction analysis. All the isolates were evaluated for their cytotoxicities against four human cancer cell lines and inhibitory activities on LPS-induced NO production in RAW264.7 cells.",

keywords = "Cytotoxic activity, Gueldenstaedtia verna, Inhibition of NO production, Leguminosae, Pterocarpans, Triterpenoids",

author = "Chengle Yin and Jinge Zhou and Yiqing Wu and Yue Cao and Tao Wu and Shoude Zhang and Honglin Li and Zhihong Cheng",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier B.V.",

year = "2015",

month = oct,

day = "1",

doi = "10.1016/j.fitote.2015.07.021",

language = "英语",

volume = "106",

pages = "46--54",

journal = "Fitoterapia",

issn = "0367-326X",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Pterocarpans and triterpenoids from Gueldenstaedtia verna

AU - Yin, Chengle

AU - Zhou, Jinge

AU - Wu, Yiqing

AU - Cao, Yue

AU - Wu, Tao

AU - Zhang, Shoude

AU - Li, Honglin

AU - Cheng, Zhihong

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Two new pterocarpan glycosides (1-2), five new triterpenoids (3-7), and 13 known analogues (14-20) were isolated from the whole plants of Gueldenstaedtia verna. These new compounds (1-7) were elucidated by extensive spectroscopic techniques including 1D (1H and 13C) and 2D NMR experiments (COSY, HSQC, HMBC and NOESY), HR-ESI-MS and chemical methods. The absolute configuration of 1 was established by the optical rotation, the comparison of experimental and calculated electronic circular dichroism (ECD) spectra and an X-ray diffraction analysis. All the isolates were evaluated for their cytotoxicities against four human cancer cell lines and inhibitory activities on LPS-induced NO production in RAW264.7 cells.

AB - Two new pterocarpan glycosides (1-2), five new triterpenoids (3-7), and 13 known analogues (14-20) were isolated from the whole plants of Gueldenstaedtia verna. These new compounds (1-7) were elucidated by extensive spectroscopic techniques including 1D (1H and 13C) and 2D NMR experiments (COSY, HSQC, HMBC and NOESY), HR-ESI-MS and chemical methods. The absolute configuration of 1 was established by the optical rotation, the comparison of experimental and calculated electronic circular dichroism (ECD) spectra and an X-ray diffraction analysis. All the isolates were evaluated for their cytotoxicities against four human cancer cell lines and inhibitory activities on LPS-induced NO production in RAW264.7 cells.

KW - Cytotoxic activity

KW - Gueldenstaedtia verna

KW - Inhibition of NO production

KW - Leguminosae

KW - Pterocarpans

KW - Triterpenoids

UR - https://www.scopus.com/pages/publications/84939789249

U2 - 10.1016/j.fitote.2015.07.021

DO - 10.1016/j.fitote.2015.07.021

M3 - 文章

C2 - 26241494

AN - SCOPUS:84939789249

SN - 0367-326X

VL - 106

SP - 46

EP - 54

JO - Fitoterapia

JF - Fitoterapia

M1 - 3238

ER -

Pterocarpans and triterpenoids from Gueldenstaedtia verna

Abstract

Keywords

UN SDGs

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