Progress of Actinidia chinensis Planch. root extract (acRoots) in cancer immunity

Lingyan Wang; Zheng Li; Miaomiao Zhang; Qi Shen; Xuemei Zhang

doi:10.1002/ctd2.171

Progress of Actinidia chinensis Planch. root extract (acRoots) in cancer immunity

Lingyan Wang^*
, Zheng Li
, Miaomiao Zhang
, Qi Shen
, Xuemei Zhang^*

^*Corresponding author for this work

Fudan University

Research output: Contribution to journal › Review article › peer-review

Abstract

Actinidia chinensis Planch. root extract (acRoots) is a famous Chinese traditional medicine used in the treatment of a variety of diseases, such as tumours and cardiovascular diseases, etc. However, its therapeutic mechanisms remain unclear. In this review, the biological features of acRoots and its chemical compositions are explored, including polysaccharides, triterpenes, phenols, flavonoids and so on. The pathogenesis of cancer involves not only genetic factors but also the microenvironment. Different types of immune cells, such as T cells, macrophages and neutrophils, play an essential role in cancer development, and acRoots was found to take part in modulating cancer immunity. Therefore, this article summarises its role in cancer immunity and unmasks the potential underlying mechanisms by incorporating our research on cancer immunity.

Original language	English
Article number	e171
Journal	Clinical and Translational Discovery
Volume	3
Issue number	1
DOIs	https://doi.org/10.1002/ctd2.171
State	Published - Feb 2023
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

acRoots
cancer immunity
kiwifruit
monomer

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10.1002/ctd2.171

Cite this

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title = "Progress of Actinidia chinensis Planch. root extract (acRoots) in cancer immunity",

abstract = "Actinidia chinensis Planch. root extract (acRoots) is a famous Chinese traditional medicine used in the treatment of a variety of diseases, such as tumours and cardiovascular diseases, etc. However, its therapeutic mechanisms remain unclear. In this review, the biological features of acRoots and its chemical compositions are explored, including polysaccharides, triterpenes, phenols, flavonoids and so on. The pathogenesis of cancer involves not only genetic factors but also the microenvironment. Different types of immune cells, such as T cells, macrophages and neutrophils, play an essential role in cancer development, and acRoots was found to take part in modulating cancer immunity. Therefore, this article summarises its role in cancer immunity and unmasks the potential underlying mechanisms by incorporating our research on cancer immunity.",

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year = "2023",

month = feb,

doi = "10.1002/ctd2.171",

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T1 - Progress of Actinidia chinensis Planch. root extract (acRoots) in cancer immunity

AU - Wang, Lingyan

AU - Li, Zheng

AU - Zhang, Miaomiao

AU - Shen, Qi

AU - Zhang, Xuemei

PY - 2023/2

Y1 - 2023/2

N2 - Actinidia chinensis Planch. root extract (acRoots) is a famous Chinese traditional medicine used in the treatment of a variety of diseases, such as tumours and cardiovascular diseases, etc. However, its therapeutic mechanisms remain unclear. In this review, the biological features of acRoots and its chemical compositions are explored, including polysaccharides, triterpenes, phenols, flavonoids and so on. The pathogenesis of cancer involves not only genetic factors but also the microenvironment. Different types of immune cells, such as T cells, macrophages and neutrophils, play an essential role in cancer development, and acRoots was found to take part in modulating cancer immunity. Therefore, this article summarises its role in cancer immunity and unmasks the potential underlying mechanisms by incorporating our research on cancer immunity.

AB - Actinidia chinensis Planch. root extract (acRoots) is a famous Chinese traditional medicine used in the treatment of a variety of diseases, such as tumours and cardiovascular diseases, etc. However, its therapeutic mechanisms remain unclear. In this review, the biological features of acRoots and its chemical compositions are explored, including polysaccharides, triterpenes, phenols, flavonoids and so on. The pathogenesis of cancer involves not only genetic factors but also the microenvironment. Different types of immune cells, such as T cells, macrophages and neutrophils, play an essential role in cancer development, and acRoots was found to take part in modulating cancer immunity. Therefore, this article summarises its role in cancer immunity and unmasks the potential underlying mechanisms by incorporating our research on cancer immunity.

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KW - cancer immunity

KW - kiwifruit

KW - monomer

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DO - 10.1002/ctd2.171

M3 - 文献综述

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SN - 2768-0622

VL - 3

JO - Clinical and Translational Discovery

JF - Clinical and Translational Discovery

IS - 1

M1 - e171

ER -

Progress of Actinidia chinensis Planch. root extract (acRoots) in cancer immunity

Abstract

UN SDGs

Keywords

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