Programming folding cooperativity of the dimeric i-motif with DNA frameworks for sensing small pH variations

Shiliang He; Mengmeng Liu; Fangfei Yin; Jiangbo Liu; Zhilei Ge; Fan Li; Min Li; Jiye Shi; Lihua Wang; Xiuhai Mao; Xiaolei Zuo; Qian Li

doi:10.1039/d1cc00266j

Programming folding cooperativity of the dimeric i-motif with DNA frameworks for sensing small pH variations

Shiliang He
, Mengmeng Liu
, Fangfei Yin
, Jiangbo Liu
, Zhilei Ge
, Fan Li
, Min Li
, Jiye Shi
, Lihua Wang
, Xiuhai Mao
, Xiaolei Zuo
, Qian Li^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

Shanghai Jiao Tong University
Chinese Academy of Sciences

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The response sensitivity of a molecular sensor is determined by the folding cooperativity of its responsive module. Using an H⁺-responsive dimeric DNA i-motif as a model, we demonstrate the enhancement of its folding cooperativity through preorganization by a DNA framework, and with it we fabricate robust intracellular pH sensors with high response sensitivity.

Original language	English
Pages (from-to)	3247-3250
Number of pages	4
Journal	Chemical Communications
Volume	57
Issue number	26
DOIs	https://doi.org/10.1039/d1cc00266j
State	Published - 4 Apr 2021

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title = "Programming folding cooperativity of the dimeric i-motif with DNA frameworks for sensing small pH variations",

abstract = "The response sensitivity of a molecular sensor is determined by the folding cooperativity of its responsive module. Using an H+-responsive dimeric DNA i-motif as a model, we demonstrate the enhancement of its folding cooperativity through preorganization by a DNA framework, and with it we fabricate robust intracellular pH sensors with high response sensitivity.",

author = "Shiliang He and Mengmeng Liu and Fangfei Yin and Jiangbo Liu and Zhilei Ge and Fan Li and Min Li and Jiye Shi and Lihua Wang and Xiuhai Mao and Xiaolei Zuo and Qian Li",

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T1 - Programming folding cooperativity of the dimeric i-motif with DNA frameworks for sensing small pH variations

AU - He, Shiliang

AU - Liu, Mengmeng

AU - Yin, Fangfei

AU - Liu, Jiangbo

AU - Ge, Zhilei

AU - Li, Fan

AU - Li, Min

AU - Shi, Jiye

AU - Wang, Lihua

AU - Mao, Xiuhai

AU - Zuo, Xiaolei

AU - Li, Qian

PY - 2021/4/4

Y1 - 2021/4/4

N2 - The response sensitivity of a molecular sensor is determined by the folding cooperativity of its responsive module. Using an H+-responsive dimeric DNA i-motif as a model, we demonstrate the enhancement of its folding cooperativity through preorganization by a DNA framework, and with it we fabricate robust intracellular pH sensors with high response sensitivity.

AB - The response sensitivity of a molecular sensor is determined by the folding cooperativity of its responsive module. Using an H+-responsive dimeric DNA i-motif as a model, we demonstrate the enhancement of its folding cooperativity through preorganization by a DNA framework, and with it we fabricate robust intracellular pH sensors with high response sensitivity.

UR - https://www.scopus.com/pages/publications/85103480686

U2 - 10.1039/d1cc00266j

DO - 10.1039/d1cc00266j

M3 - 文章

C2 - 33646233

AN - SCOPUS:85103480686

SN - 1359-7345

VL - 57

SP - 3247

EP - 3250

JO - Chemical Communications

JF - Chemical Communications

IS - 26

ER -

Programming folding cooperativity of the dimeric i-motif with DNA frameworks for sensing small pH variations

Abstract

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