Programmable drug release using bioresponsive mesoporous silica nanoparticles for site-specific oral drug delivery

Amirali Popat; Siddharth Jambhrunkar; Jun Zhang; Jie Yang; Honwei Zhang; Anand Meka; Chengzhong Yu

doi:10.1039/c4cc00620h

Programmable drug release using bioresponsive mesoporous silica nanoparticles for site-specific oral drug delivery

Amirali Popat, Siddharth Jambhrunkar, Jun Zhang, Jie Yang, Honwei Zhang, Anand Meka, Chengzhong Yu

University of Queensland

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

Novel mesoporous silica nanoparticles (MSNs) responsive to multiple biological stimuli (pH and enzymes) were prepared through conjugation with a structure modified soy protein isolate. The particles show an extremely high pro-drug (sulfasalazine) loading with programmable drug release in simulated gastrointestinal fluid.

Original language	English
Pages (from-to)	5547-5550
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	42
DOIs	https://doi.org/10.1039/c4cc00620h
State	Published - 29 Apr 2014
Externally published	Yes

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10.1039/c4cc00620h

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title = "Programmable drug release using bioresponsive mesoporous silica nanoparticles for site-specific oral drug delivery",

abstract = "Novel mesoporous silica nanoparticles (MSNs) responsive to multiple biological stimuli (pH and enzymes) were prepared through conjugation with a structure modified soy protein isolate. The particles show an extremely high pro-drug (sulfasalazine) loading with programmable drug release in simulated gastrointestinal fluid.",

author = "Amirali Popat and Siddharth Jambhrunkar and Jun Zhang and Jie Yang and Honwei Zhang and Anand Meka and Chengzhong Yu",

year = "2014",

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language = "英语",

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T1 - Programmable drug release using bioresponsive mesoporous silica nanoparticles for site-specific oral drug delivery

AU - Popat, Amirali

AU - Jambhrunkar, Siddharth

AU - Zhang, Jun

AU - Yang, Jie

AU - Zhang, Honwei

AU - Meka, Anand

AU - Yu, Chengzhong

PY - 2014/4/29

Y1 - 2014/4/29

N2 - Novel mesoporous silica nanoparticles (MSNs) responsive to multiple biological stimuli (pH and enzymes) were prepared through conjugation with a structure modified soy protein isolate. The particles show an extremely high pro-drug (sulfasalazine) loading with programmable drug release in simulated gastrointestinal fluid.

AB - Novel mesoporous silica nanoparticles (MSNs) responsive to multiple biological stimuli (pH and enzymes) were prepared through conjugation with a structure modified soy protein isolate. The particles show an extremely high pro-drug (sulfasalazine) loading with programmable drug release in simulated gastrointestinal fluid.

UR - https://www.scopus.com/pages/publications/84899648022

U2 - 10.1039/c4cc00620h

DO - 10.1039/c4cc00620h

M3 - 文章

C2 - 24603852

AN - SCOPUS:84899648022

SN - 1359-7345

VL - 50

SP - 5547

EP - 5550

JO - Chemical Communications

JF - Chemical Communications

IS - 42

ER -

Programmable drug release using bioresponsive mesoporous silica nanoparticles for site-specific oral drug delivery

Abstract

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