Preparation of novel hollow mesoporous silica spheres and their sustained-release property

Yufang Zhu; Jianlin Shi; Weihua Shen; Hangrong Chen; Xiaoping Dong; Meilin Ruan

doi:10.1088/0957-4484/16/11/027

Preparation of novel hollow mesoporous silica spheres and their sustained-release property

Yufang Zhu
, Jianlin Shi^*
, Weihua Shen
, Hangrong Chen
, Xiaoping Dong
, Meilin Ruan

^*Corresponding author for this work

CAS - Shanghai Institute of Ceramics

Research output: Contribution to journal › Article › peer-review

184 Scopus citations

Abstract

Novel hollow mesoporous silica spheres (HMSs) with uniform size and morphology have been successfully synthesized in a facile route using poly(vinylpyrrolidone) (PVP) and cetyltrimethylammonium bromide (CTAB) as co-templates at room temperature. XRD, N₂ adsorption-desorption analysis, FE-SEM, and TEM are used for the characterization of the structure. The hexagonally ordered pore channels are formed on the shell. Ibuprofen (IBU) as a model drug is used to examine the storage capacity and the release behaviour of drug molecules. The storage capacity of hollow mesoporous silica spheres can reach 1133 ± 52.4 mg g^-1 for ibuprofen, which is three times higher than that of conventional mesoporous materials previously reported (337 mg g^-1), and the storage capacity is adjustable in a wide range. Furthermore, this system also shows a sustained-release behaviour. The release rates from the IBU-HMSs system (IBU stored in HMSs) increase with the decrease of pH values and the release process follows a Fick's law.

Original language	English
Pages (from-to)	2633-2638
Number of pages	6
Journal	Nanotechnology
Volume	16
Issue number	11
DOIs	https://doi.org/10.1088/0957-4484/16/11/027
State	Published - 1 Nov 2005
Externally published	Yes

Access to Document

10.1088/0957-4484/16/11/027

Cite this

@article{e0953a13c53942c898afa8053f99e0ac,

title = "Preparation of novel hollow mesoporous silica spheres and their sustained-release property",

abstract = "Novel hollow mesoporous silica spheres (HMSs) with uniform size and morphology have been successfully synthesized in a facile route using poly(vinylpyrrolidone) (PVP) and cetyltrimethylammonium bromide (CTAB) as co-templates at room temperature. XRD, N2 adsorption-desorption analysis, FE-SEM, and TEM are used for the characterization of the structure. The hexagonally ordered pore channels are formed on the shell. Ibuprofen (IBU) as a model drug is used to examine the storage capacity and the release behaviour of drug molecules. The storage capacity of hollow mesoporous silica spheres can reach 1133 ± 52.4 mg g-1 for ibuprofen, which is three times higher than that of conventional mesoporous materials previously reported (337 mg g-1), and the storage capacity is adjustable in a wide range. Furthermore, this system also shows a sustained-release behaviour. The release rates from the IBU-HMSs system (IBU stored in HMSs) increase with the decrease of pH values and the release process follows a Fick's law.",

author = "Yufang Zhu and Jianlin Shi and Weihua Shen and Hangrong Chen and Xiaoping Dong and Meilin Ruan",

year = "2005",

month = nov,

day = "1",

doi = "10.1088/0957-4484/16/11/027",

language = "英语",

volume = "16",

pages = "2633--2638",

journal = "Nanotechnology",

issn = "0957-4484",

publisher = "IOP Publishing Ltd.",

number = "11",

}

TY - JOUR

T1 - Preparation of novel hollow mesoporous silica spheres and their sustained-release property

AU - Zhu, Yufang

AU - Shi, Jianlin

AU - Shen, Weihua

AU - Chen, Hangrong

AU - Dong, Xiaoping

AU - Ruan, Meilin

PY - 2005/11/1

Y1 - 2005/11/1

N2 - Novel hollow mesoporous silica spheres (HMSs) with uniform size and morphology have been successfully synthesized in a facile route using poly(vinylpyrrolidone) (PVP) and cetyltrimethylammonium bromide (CTAB) as co-templates at room temperature. XRD, N2 adsorption-desorption analysis, FE-SEM, and TEM are used for the characterization of the structure. The hexagonally ordered pore channels are formed on the shell. Ibuprofen (IBU) as a model drug is used to examine the storage capacity and the release behaviour of drug molecules. The storage capacity of hollow mesoporous silica spheres can reach 1133 ± 52.4 mg g-1 for ibuprofen, which is three times higher than that of conventional mesoporous materials previously reported (337 mg g-1), and the storage capacity is adjustable in a wide range. Furthermore, this system also shows a sustained-release behaviour. The release rates from the IBU-HMSs system (IBU stored in HMSs) increase with the decrease of pH values and the release process follows a Fick's law.

AB - Novel hollow mesoporous silica spheres (HMSs) with uniform size and morphology have been successfully synthesized in a facile route using poly(vinylpyrrolidone) (PVP) and cetyltrimethylammonium bromide (CTAB) as co-templates at room temperature. XRD, N2 adsorption-desorption analysis, FE-SEM, and TEM are used for the characterization of the structure. The hexagonally ordered pore channels are formed on the shell. Ibuprofen (IBU) as a model drug is used to examine the storage capacity and the release behaviour of drug molecules. The storage capacity of hollow mesoporous silica spheres can reach 1133 ± 52.4 mg g-1 for ibuprofen, which is three times higher than that of conventional mesoporous materials previously reported (337 mg g-1), and the storage capacity is adjustable in a wide range. Furthermore, this system also shows a sustained-release behaviour. The release rates from the IBU-HMSs system (IBU stored in HMSs) increase with the decrease of pH values and the release process follows a Fick's law.

UR - https://www.scopus.com/pages/publications/26444533377

U2 - 10.1088/0957-4484/16/11/027

DO - 10.1088/0957-4484/16/11/027

M3 - 文章

AN - SCOPUS:26444533377

SN - 0957-4484

VL - 16

SP - 2633

EP - 2638

JO - Nanotechnology

JF - Nanotechnology

IS - 11

ER -

Preparation of novel hollow mesoporous silica spheres and their sustained-release property

Abstract

Access to Document

Other files and links

Fingerprint

Cite this