Preparation of nanosized CoHCF modified electrode and its application to electroanalysis of hemoglobin

Mei Chuan Liu; Ping Li; Li Zhang; Yue Zhong Xian; Hong Chun Ding; Cheng Lin Zhang; Fen Fen Zhang; Li Tong Jin

doi:10.1002/cjoc.200590983

Preparation of nanosized CoHCF modified electrode and its application to electroanalysis of hemoglobin

Mei Chuan Liu^*
, Ping Li
, Li Zhang
, Yue Zhong Xian
, Hong Chun Ding
, Cheng Lin Zhang
, Fen Fen Zhang
, Li Tong Jin

^*Corresponding author for this work

East China Normal University

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

A cobalt hexacyanoferrate (CoHCF) nanoparticle (size ca. 60 nm) chemically modified electrode (CME) was fabricated and the electrochemical behavior of hemoglobin (Hb) at this nanosized CoHCF CME was studied. In comparison with a bare glassy carbon electrode (GCE) and a general CoHCF CME electrodeposited in a traditional manner, the present nanosized CoHCF CME performed efficiently electrocatalytic reduction for Hb with relatively high sensitivity, stability, and longlife. Combined with liquid chromatography (LC), the nanosized CoHCF CME was used as the electrochemical detector of Hb in the established flow injection analysis-electrochemical determination (FIA-ECD) system. The peak current was a linear function of concentrations in the range from 2.5 × 10^-8 to 5.0 × 10^-6 mol/L for Hb, with detection limit of 1.4 × 10^-8 mol/L. The FIA-ECD system has been successfully applied to assess the Hb content of clinic blood samples with advantages of sensitiveness, speediness, easy control and small sample-consumption.

Original language	English
Pages (from-to)	983-989
Number of pages	7
Journal	Chinese Journal of Chemistry
Volume	23
Issue number	8
DOIs	https://doi.org/10.1002/cjoc.200590983
State	Published - Aug 2005

Keywords

Clinic blood
Direct electrochemical determination
Flow injection analysis-electrochemical determination
Hemoglobin
Nanosized cobalt hexacyanoferrate chemically modified electrode

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10.1002/cjoc.200590983

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@article{b8349879488c47bb9c4d6c41cfa89058,

title = "Preparation of nanosized CoHCF modified electrode and its application to electroanalysis of hemoglobin",

abstract = "A cobalt hexacyanoferrate (CoHCF) nanoparticle (size ca. 60 nm) chemically modified electrode (CME) was fabricated and the electrochemical behavior of hemoglobin (Hb) at this nanosized CoHCF CME was studied. In comparison with a bare glassy carbon electrode (GCE) and a general CoHCF CME electrodeposited in a traditional manner, the present nanosized CoHCF CME performed efficiently electrocatalytic reduction for Hb with relatively high sensitivity, stability, and longlife. Combined with liquid chromatography (LC), the nanosized CoHCF CME was used as the electrochemical detector of Hb in the established flow injection analysis-electrochemical determination (FIA-ECD) system. The peak current was a linear function of concentrations in the range from 2.5 × 10-8 to 5.0 × 10-6 mol/L for Hb, with detection limit of 1.4 × 10-8 mol/L. The FIA-ECD system has been successfully applied to assess the Hb content of clinic blood samples with advantages of sensitiveness, speediness, easy control and small sample-consumption.",

keywords = "Clinic blood, Direct electrochemical determination, Flow injection analysis-electrochemical determination, Hemoglobin, Nanosized cobalt hexacyanoferrate chemically modified electrode",

author = "Liu, \{Mei Chuan\} and Ping Li and Li Zhang and Xian, \{Yue Zhong\} and Ding, \{Hong Chun\} and Zhang, \{Cheng Lin\} and Zhang, \{Fen Fen\} and Jin, \{Li Tong\}",

year = "2005",

month = aug,

doi = "10.1002/cjoc.200590983",

language = "英语",

volume = "23",

pages = "983--989",

journal = "Chinese Journal of Chemistry",

issn = "1001-604X",

publisher = "John Wiley and Sons Inc",

number = "8",

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TY - JOUR

T1 - Preparation of nanosized CoHCF modified electrode and its application to electroanalysis of hemoglobin

AU - Liu, Mei Chuan

AU - Li, Ping

AU - Zhang, Li

AU - Xian, Yue Zhong

AU - Ding, Hong Chun

AU - Zhang, Cheng Lin

AU - Zhang, Fen Fen

AU - Jin, Li Tong

PY - 2005/8

Y1 - 2005/8

N2 - A cobalt hexacyanoferrate (CoHCF) nanoparticle (size ca. 60 nm) chemically modified electrode (CME) was fabricated and the electrochemical behavior of hemoglobin (Hb) at this nanosized CoHCF CME was studied. In comparison with a bare glassy carbon electrode (GCE) and a general CoHCF CME electrodeposited in a traditional manner, the present nanosized CoHCF CME performed efficiently electrocatalytic reduction for Hb with relatively high sensitivity, stability, and longlife. Combined with liquid chromatography (LC), the nanosized CoHCF CME was used as the electrochemical detector of Hb in the established flow injection analysis-electrochemical determination (FIA-ECD) system. The peak current was a linear function of concentrations in the range from 2.5 × 10-8 to 5.0 × 10-6 mol/L for Hb, with detection limit of 1.4 × 10-8 mol/L. The FIA-ECD system has been successfully applied to assess the Hb content of clinic blood samples with advantages of sensitiveness, speediness, easy control and small sample-consumption.

AB - A cobalt hexacyanoferrate (CoHCF) nanoparticle (size ca. 60 nm) chemically modified electrode (CME) was fabricated and the electrochemical behavior of hemoglobin (Hb) at this nanosized CoHCF CME was studied. In comparison with a bare glassy carbon electrode (GCE) and a general CoHCF CME electrodeposited in a traditional manner, the present nanosized CoHCF CME performed efficiently electrocatalytic reduction for Hb with relatively high sensitivity, stability, and longlife. Combined with liquid chromatography (LC), the nanosized CoHCF CME was used as the electrochemical detector of Hb in the established flow injection analysis-electrochemical determination (FIA-ECD) system. The peak current was a linear function of concentrations in the range from 2.5 × 10-8 to 5.0 × 10-6 mol/L for Hb, with detection limit of 1.4 × 10-8 mol/L. The FIA-ECD system has been successfully applied to assess the Hb content of clinic blood samples with advantages of sensitiveness, speediness, easy control and small sample-consumption.

KW - Clinic blood

KW - Direct electrochemical determination

KW - Flow injection analysis-electrochemical determination

KW - Hemoglobin

KW - Nanosized cobalt hexacyanoferrate chemically modified electrode

UR - https://www.scopus.com/pages/publications/25144487193

U2 - 10.1002/cjoc.200590983

DO - 10.1002/cjoc.200590983

M3 - 文章

AN - SCOPUS:25144487193

SN - 1001-604X

VL - 23

SP - 983

EP - 989

JO - Chinese Journal of Chemistry

JF - Chinese Journal of Chemistry

IS - 8

ER -

Preparation of nanosized CoHCF modified electrode and its application to electroanalysis of hemoglobin

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