Preparation of mesoporous calcium doped silica spheres with narrow size dispersion and their drug loading and degradation behavior

Xia Li; Lingxia Zhang; Xiaoping Dong; Jian Liang; Jianlin Shi

doi:10.1016/j.micromeso.2006.12.048

Preparation of mesoporous calcium doped silica spheres with narrow size dispersion and their drug loading and degradation behavior

Xia Li
, Lingxia Zhang
, Xiaoping Dong
, Jian Liang
, Jianlin Shi^*

^*Corresponding author for this work

CAS - Shanghai Institute of Ceramics

Research output: Contribution to journal › Article › peer-review

180 Scopus citations

Abstract

The mesoporous calcium doped silica spheres (CaMS) as well as silica spheres (MS) have been successfully synthesized by a simple one-step method. MS showed a uniform sphere morphology and CaMS exhibited an ellipse morphology with the long axis of around 100 nm. The amount of CaO in CaMS was up to 8.18 wt%. The mesoporous structures of MS and CaMS were studied by X-ray diffraction, transmission electron microscopy and liquid nitrogen adsorption. The results showed that the addition of Ca(NO₃)₂ led to the decreased cell parameters and the increased pore size of CaMS compared to MS. Ibuprofen (IBU) drug storage capacities and release rate were investigated and there was no obvious difference between MS and CaMS. The degradation results showed that CaMS had a significant higher degradation rate than MS. The mesoporous calcium doped silica spheres have potential as drug carrier for controlled-release application.

Original language	English
Pages (from-to)	151-158
Number of pages	8
Journal	Microporous and Mesoporous Materials
Volume	102
Issue number	1-3
DOIs	https://doi.org/10.1016/j.micromeso.2006.12.048
State	Published - 4 May 2007
Externally published	Yes

Keywords

Degradation
Drug release
Ibuprofen
Mesoporous calcium doped silica spheres

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10.1016/j.micromeso.2006.12.048

Cite this

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title = "Preparation of mesoporous calcium doped silica spheres with narrow size dispersion and their drug loading and degradation behavior",

abstract = "The mesoporous calcium doped silica spheres (CaMS) as well as silica spheres (MS) have been successfully synthesized by a simple one-step method. MS showed a uniform sphere morphology and CaMS exhibited an ellipse morphology with the long axis of around 100 nm. The amount of CaO in CaMS was up to 8.18 wt\%. The mesoporous structures of MS and CaMS were studied by X-ray diffraction, transmission electron microscopy and liquid nitrogen adsorption. The results showed that the addition of Ca(NO3)2 led to the decreased cell parameters and the increased pore size of CaMS compared to MS. Ibuprofen (IBU) drug storage capacities and release rate were investigated and there was no obvious difference between MS and CaMS. The degradation results showed that CaMS had a significant higher degradation rate than MS. The mesoporous calcium doped silica spheres have potential as drug carrier for controlled-release application.",

keywords = "Degradation, Drug release, Ibuprofen, Mesoporous calcium doped silica spheres",

author = "Xia Li and Lingxia Zhang and Xiaoping Dong and Jian Liang and Jianlin Shi",

year = "2007",

month = may,

day = "4",

doi = "10.1016/j.micromeso.2006.12.048",

language = "英语",

volume = "102",

pages = "151--158",

journal = "Microporous and Mesoporous Materials",

issn = "1387-1811",

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number = "1-3",

}

TY - JOUR

T1 - Preparation of mesoporous calcium doped silica spheres with narrow size dispersion and their drug loading and degradation behavior

AU - Li, Xia

AU - Zhang, Lingxia

AU - Dong, Xiaoping

AU - Liang, Jian

AU - Shi, Jianlin

PY - 2007/5/4

Y1 - 2007/5/4

N2 - The mesoporous calcium doped silica spheres (CaMS) as well as silica spheres (MS) have been successfully synthesized by a simple one-step method. MS showed a uniform sphere morphology and CaMS exhibited an ellipse morphology with the long axis of around 100 nm. The amount of CaO in CaMS was up to 8.18 wt%. The mesoporous structures of MS and CaMS were studied by X-ray diffraction, transmission electron microscopy and liquid nitrogen adsorption. The results showed that the addition of Ca(NO3)2 led to the decreased cell parameters and the increased pore size of CaMS compared to MS. Ibuprofen (IBU) drug storage capacities and release rate were investigated and there was no obvious difference between MS and CaMS. The degradation results showed that CaMS had a significant higher degradation rate than MS. The mesoporous calcium doped silica spheres have potential as drug carrier for controlled-release application.

AB - The mesoporous calcium doped silica spheres (CaMS) as well as silica spheres (MS) have been successfully synthesized by a simple one-step method. MS showed a uniform sphere morphology and CaMS exhibited an ellipse morphology with the long axis of around 100 nm. The amount of CaO in CaMS was up to 8.18 wt%. The mesoporous structures of MS and CaMS were studied by X-ray diffraction, transmission electron microscopy and liquid nitrogen adsorption. The results showed that the addition of Ca(NO3)2 led to the decreased cell parameters and the increased pore size of CaMS compared to MS. Ibuprofen (IBU) drug storage capacities and release rate were investigated and there was no obvious difference between MS and CaMS. The degradation results showed that CaMS had a significant higher degradation rate than MS. The mesoporous calcium doped silica spheres have potential as drug carrier for controlled-release application.

KW - Degradation

KW - Drug release

KW - Ibuprofen

KW - Mesoporous calcium doped silica spheres

UR - https://www.scopus.com/pages/publications/34247141120

U2 - 10.1016/j.micromeso.2006.12.048

DO - 10.1016/j.micromeso.2006.12.048

M3 - 文章

AN - SCOPUS:34247141120

SN - 1387-1811

VL - 102

SP - 151

EP - 158

JO - Microporous and Mesoporous Materials

JF - Microporous and Mesoporous Materials

IS - 1-3

ER -

Preparation of mesoporous calcium doped silica spheres with narrow size dispersion and their drug loading and degradation behavior

Abstract

Keywords

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