Preparation and properties of a novel drug delivery system with both magnetic and biomolecular targeting

Yong Yang; Ji Sen Jiang; Bing Du; Zhi Feng Gan; Min Qian; Ping Zhang

doi:10.1007/s10856-008-3577-0

Preparation and properties of a novel drug delivery system with both magnetic and biomolecular targeting

Yong Yang
, Ji Sen Jiang^*
, Bing Du
, Zhi Feng Gan
, Min Qian
, Ping Zhang

^*Corresponding author for this work

School of Life Sciences

East China Normal University

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

Abstract

By loading doxorubicin (DOX) on 5-carboxyl-fluorescein (FAM) labeled AGKGTPSLETTP peptide (A54) coupled starch-coated iron oxide nanoparticles (SIONs), we prepared a novel aqueous drug delivery system with both magnetic and biomolecular targeting, which was specific to human hepatocellular carcinoma cell line BEL-7402. The saturated extent of adsorption reached 2.0 mg DOX/mg A54-SIONs at 28°C, which provided a rather high dose of DOX loading for application. Tests in vitro demonstrated the specificity of DOX-loaded A54-SIONs to BEL-7402 cells. The microscopy images proved that DOX-loaded A54-SIONs were successfully targeted to tumor tissue of nude mice with an external magnetic field in vivo. MTT assay showed higher cytostatic effect of DOX-loaded A54-SIONs to hepatocellular carcinoma cells BEL-7402 than that of DOX-loaded SIONs.

Original language	English
Pages (from-to)	301-307
Number of pages	7
Journal	Journal of Materials Science: Materials in Medicine
Volume	20
Issue number	1
DOIs	https://doi.org/10.1007/s10856-008-3577-0
State	Published - Jan 2009

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title = "Preparation and properties of a novel drug delivery system with both magnetic and biomolecular targeting",

abstract = "By loading doxorubicin (DOX) on 5-carboxyl-fluorescein (FAM) labeled AGKGTPSLETTP peptide (A54) coupled starch-coated iron oxide nanoparticles (SIONs), we prepared a novel aqueous drug delivery system with both magnetic and biomolecular targeting, which was specific to human hepatocellular carcinoma cell line BEL-7402. The saturated extent of adsorption reached 2.0 mg DOX/mg A54-SIONs at 28°C, which provided a rather high dose of DOX loading for application. Tests in vitro demonstrated the specificity of DOX-loaded A54-SIONs to BEL-7402 cells. The microscopy images proved that DOX-loaded A54-SIONs were successfully targeted to tumor tissue of nude mice with an external magnetic field in vivo. MTT assay showed higher cytostatic effect of DOX-loaded A54-SIONs to hepatocellular carcinoma cells BEL-7402 than that of DOX-loaded SIONs.",

author = "Yong Yang and Jiang, \{Ji Sen\} and Bing Du and Gan, \{Zhi Feng\} and Min Qian and Ping Zhang",

year = "2009",

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doi = "10.1007/s10856-008-3577-0",

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T1 - Preparation and properties of a novel drug delivery system with both magnetic and biomolecular targeting

AU - Yang, Yong

AU - Jiang, Ji Sen

AU - Du, Bing

AU - Gan, Zhi Feng

AU - Qian, Min

AU - Zhang, Ping

PY - 2009/1

Y1 - 2009/1

N2 - By loading doxorubicin (DOX) on 5-carboxyl-fluorescein (FAM) labeled AGKGTPSLETTP peptide (A54) coupled starch-coated iron oxide nanoparticles (SIONs), we prepared a novel aqueous drug delivery system with both magnetic and biomolecular targeting, which was specific to human hepatocellular carcinoma cell line BEL-7402. The saturated extent of adsorption reached 2.0 mg DOX/mg A54-SIONs at 28°C, which provided a rather high dose of DOX loading for application. Tests in vitro demonstrated the specificity of DOX-loaded A54-SIONs to BEL-7402 cells. The microscopy images proved that DOX-loaded A54-SIONs were successfully targeted to tumor tissue of nude mice with an external magnetic field in vivo. MTT assay showed higher cytostatic effect of DOX-loaded A54-SIONs to hepatocellular carcinoma cells BEL-7402 than that of DOX-loaded SIONs.

AB - By loading doxorubicin (DOX) on 5-carboxyl-fluorescein (FAM) labeled AGKGTPSLETTP peptide (A54) coupled starch-coated iron oxide nanoparticles (SIONs), we prepared a novel aqueous drug delivery system with both magnetic and biomolecular targeting, which was specific to human hepatocellular carcinoma cell line BEL-7402. The saturated extent of adsorption reached 2.0 mg DOX/mg A54-SIONs at 28°C, which provided a rather high dose of DOX loading for application. Tests in vitro demonstrated the specificity of DOX-loaded A54-SIONs to BEL-7402 cells. The microscopy images proved that DOX-loaded A54-SIONs were successfully targeted to tumor tissue of nude mice with an external magnetic field in vivo. MTT assay showed higher cytostatic effect of DOX-loaded A54-SIONs to hepatocellular carcinoma cells BEL-7402 than that of DOX-loaded SIONs.

UR - https://www.scopus.com/pages/publications/58549087527

U2 - 10.1007/s10856-008-3577-0

DO - 10.1007/s10856-008-3577-0

M3 - 文章

C2 - 18791664

AN - SCOPUS:58549087527

SN - 0957-4530

VL - 20

SP - 301

EP - 307

JO - Journal of Materials Science: Materials in Medicine

JF - Journal of Materials Science: Materials in Medicine

IS - 1

ER -

Preparation and properties of a novel drug delivery system with both magnetic and biomolecular targeting

Abstract

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