Preparation and characterization of amino-functionalized magnetic nanogels via photopolymerization for MRI applications

Yanbao Gong; Mingxia Fan; Feng Gao; Jun Hong; Shunying Liu; Shufang Luo; Jiahui Yu; Jin Huang

doi:10.1016/j.colsurfb.2009.02.012

Preparation and characterization of amino-functionalized magnetic nanogels via photopolymerization for MRI applications

Yanbao Gong
, Mingxia Fan
, Feng Gao
, Jun Hong
, Shunying Liu
, Shufang Luo
, Jiahui Yu^*
, Jin Huang

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

To design peptide-targeted iron oxide as magnetic resonance imaging (MRI) contrast agents, amino-functionalized magnetic nanogels were prepared by using N-(2-aminoethyl) methacrylamide hydrochloride (AEM·HCl) as monomer via new photochemical approach. Their chemical structure and composition were characterized by Fourier transform infrared spectra (FTIR) and thermogravimetric analyses (TGA). The core-shell structure of magnetic nanogels was confirmed by high-resolution transmission electron microscopy (HRTEM). The good storage stability, high magnetic content (88.7%), high saturation magnetizations and superparamagnetic behavior suggested their great potentials as MRI contrast agents, which were confirmed by their measurements of r₂ and coronal image of the crossing of mouse kidney.

Original language	English
Pages (from-to)	243-247
Number of pages	5
Journal	Colloids and Surfaces B: Biointerfaces
Volume	71
Issue number	2
DOIs	https://doi.org/10.1016/j.colsurfb.2009.02.012
State	Published - 1 Jul 2009

Keywords

Amino-functionalized
Core-shell magnetic nanogels
Magnetic resonance imaging (MRI)
Photopolymerization
Superparamagnetism

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10.1016/j.colsurfb.2009.02.012

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title = "Preparation and characterization of amino-functionalized magnetic nanogels via photopolymerization for MRI applications",

abstract = "To design peptide-targeted iron oxide as magnetic resonance imaging (MRI) contrast agents, amino-functionalized magnetic nanogels were prepared by using N-(2-aminoethyl) methacrylamide hydrochloride (AEM·HCl) as monomer via new photochemical approach. Their chemical structure and composition were characterized by Fourier transform infrared spectra (FTIR) and thermogravimetric analyses (TGA). The core-shell structure of magnetic nanogels was confirmed by high-resolution transmission electron microscopy (HRTEM). The good storage stability, high magnetic content (88.7\%), high saturation magnetizations and superparamagnetic behavior suggested their great potentials as MRI contrast agents, which were confirmed by their measurements of r2 and coronal image of the crossing of mouse kidney.",

keywords = "Amino-functionalized, Core-shell magnetic nanogels, Magnetic resonance imaging (MRI), Photopolymerization, Superparamagnetism",

author = "Yanbao Gong and Mingxia Fan and Feng Gao and Jun Hong and Shunying Liu and Shufang Luo and Jiahui Yu and Jin Huang",

year = "2009",

month = jul,

day = "1",

doi = "10.1016/j.colsurfb.2009.02.012",

language = "英语",

volume = "71",

pages = "243--247",

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issn = "0927-7765",

publisher = "Elsevier B.V.",

number = "2",

}

TY - JOUR

T1 - Preparation and characterization of amino-functionalized magnetic nanogels via photopolymerization for MRI applications

AU - Gong, Yanbao

AU - Fan, Mingxia

AU - Gao, Feng

AU - Hong, Jun

AU - Liu, Shunying

AU - Luo, Shufang

AU - Yu, Jiahui

AU - Huang, Jin

PY - 2009/7/1

Y1 - 2009/7/1

N2 - To design peptide-targeted iron oxide as magnetic resonance imaging (MRI) contrast agents, amino-functionalized magnetic nanogels were prepared by using N-(2-aminoethyl) methacrylamide hydrochloride (AEM·HCl) as monomer via new photochemical approach. Their chemical structure and composition were characterized by Fourier transform infrared spectra (FTIR) and thermogravimetric analyses (TGA). The core-shell structure of magnetic nanogels was confirmed by high-resolution transmission electron microscopy (HRTEM). The good storage stability, high magnetic content (88.7%), high saturation magnetizations and superparamagnetic behavior suggested their great potentials as MRI contrast agents, which were confirmed by their measurements of r2 and coronal image of the crossing of mouse kidney.

AB - To design peptide-targeted iron oxide as magnetic resonance imaging (MRI) contrast agents, amino-functionalized magnetic nanogels were prepared by using N-(2-aminoethyl) methacrylamide hydrochloride (AEM·HCl) as monomer via new photochemical approach. Their chemical structure and composition were characterized by Fourier transform infrared spectra (FTIR) and thermogravimetric analyses (TGA). The core-shell structure of magnetic nanogels was confirmed by high-resolution transmission electron microscopy (HRTEM). The good storage stability, high magnetic content (88.7%), high saturation magnetizations and superparamagnetic behavior suggested their great potentials as MRI contrast agents, which were confirmed by their measurements of r2 and coronal image of the crossing of mouse kidney.

KW - Amino-functionalized

KW - Core-shell magnetic nanogels

KW - Magnetic resonance imaging (MRI)

KW - Photopolymerization

KW - Superparamagnetism

UR - https://www.scopus.com/pages/publications/67349158292

U2 - 10.1016/j.colsurfb.2009.02.012

DO - 10.1016/j.colsurfb.2009.02.012

M3 - 文章

C2 - 19278838

AN - SCOPUS:67349158292

SN - 0927-7765

VL - 71

SP - 243

EP - 247

JO - Colloids and Surfaces B: Biointerfaces

JF - Colloids and Surfaces B: Biointerfaces

IS - 2

ER -

Preparation and characterization of amino-functionalized magnetic nanogels via photopolymerization for MRI applications

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Keywords

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