Abstract
Camptothecin (CPT), a plant alkaloid isolated from Camptotheca acuminata, has an extremely low solubility in aqueous medium, which presents a major challenge during drug formulation in clinical trails. In the present study we investigated the potential of poly(amidoamine) (PAMAM) dendrimers as drug carriers of CPT through aqueous solubility studies. Results showed that the aqueous solubility of CPT was significantly increased by PAMAM dendrimers. The effect of PAMAM generation on CPT solubility was also evaluated. These studies indicated that PAMAM dendrimers might be considered as biocompatible carriers of CPT.
| Original language | English |
|---|---|
| Pages (from-to) | 1791-1795 |
| Number of pages | 5 |
| Journal | European Journal of Medicinal Chemistry |
| Volume | 43 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2008 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Anti-cancer drugs
- Camptothecin
- Drug carrier
- PAMAM
- Poly(amidoamine) dendrimers
- Solubility
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