Positive selection of the bat interferon alpha gene family

Guimei He; Beibei He; Paul A. Racey; Jie Cui

doi:10.1007/s10528-010-9365-9

Positive selection of the bat interferon alpha gene family

Guimei He
, Beibei He
, Paul A. Racey
, Jie Cui^*

^*Corresponding author for this work

School of Life Sciences

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Type I interferons (IFNs) are produced by leukocytes in reaction to pathogenic infection and function as positive mediators in antiviral pathways. Among IFNs, IFN alpha (IFNA) has the largest number of family members and plays an important role against the invasion of pathogens. Bats are putative and proven vectors for numerous viruses; however, the evolution of the IFNA family in bats has not been addressed. Here, we construct a phylogeny of IFNA families, including one fruit bat (Dobsonia viridis), with other vertebrates as references. Site-model estimation reveals that positive selection has shaped bat IFNA genes, showing that positive selection drives the evolution of bat IFNA genes.

Original language	English
Pages (from-to)	840-846
Number of pages	7
Journal	Biochemical Genetics
Volume	48
Issue number	9-10
DOIs	https://doi.org/10.1007/s10528-010-9365-9
State	Published - Oct 2010

Keywords

Bat
Gene family
Interferon alpha
Positive selection

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10.1007/s10528-010-9365-9

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title = "Positive selection of the bat interferon alpha gene family",

abstract = "Type I interferons (IFNs) are produced by leukocytes in reaction to pathogenic infection and function as positive mediators in antiviral pathways. Among IFNs, IFN alpha (IFNA) has the largest number of family members and plays an important role against the invasion of pathogens. Bats are putative and proven vectors for numerous viruses; however, the evolution of the IFNA family in bats has not been addressed. Here, we construct a phylogeny of IFNA families, including one fruit bat (Dobsonia viridis), with other vertebrates as references. Site-model estimation reveals that positive selection has shaped bat IFNA genes, showing that positive selection drives the evolution of bat IFNA genes.",

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author = "Guimei He and Beibei He and Racey, \{Paul A.\} and Jie Cui",

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doi = "10.1007/s10528-010-9365-9",

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T1 - Positive selection of the bat interferon alpha gene family

AU - He, Guimei

AU - He, Beibei

AU - Racey, Paul A.

AU - Cui, Jie

PY - 2010/10

Y1 - 2010/10

N2 - Type I interferons (IFNs) are produced by leukocytes in reaction to pathogenic infection and function as positive mediators in antiviral pathways. Among IFNs, IFN alpha (IFNA) has the largest number of family members and plays an important role against the invasion of pathogens. Bats are putative and proven vectors for numerous viruses; however, the evolution of the IFNA family in bats has not been addressed. Here, we construct a phylogeny of IFNA families, including one fruit bat (Dobsonia viridis), with other vertebrates as references. Site-model estimation reveals that positive selection has shaped bat IFNA genes, showing that positive selection drives the evolution of bat IFNA genes.

AB - Type I interferons (IFNs) are produced by leukocytes in reaction to pathogenic infection and function as positive mediators in antiviral pathways. Among IFNs, IFN alpha (IFNA) has the largest number of family members and plays an important role against the invasion of pathogens. Bats are putative and proven vectors for numerous viruses; however, the evolution of the IFNA family in bats has not been addressed. Here, we construct a phylogeny of IFNA families, including one fruit bat (Dobsonia viridis), with other vertebrates as references. Site-model estimation reveals that positive selection has shaped bat IFNA genes, showing that positive selection drives the evolution of bat IFNA genes.

KW - Bat

KW - Gene family

KW - Interferon alpha

KW - Positive selection

UR - https://www.scopus.com/pages/publications/77957803511

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M3 - 文章

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AN - SCOPUS:77957803511

SN - 0006-2928

VL - 48

SP - 840

EP - 846

JO - Biochemical Genetics

JF - Biochemical Genetics

IS - 9-10

ER -

Positive selection of the bat interferon alpha gene family

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Keywords

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