Polyamidoamine (PAMAM) dendrimers as biocompatible carriers of quinolone antimicrobials: An in vitro study

Yiyun Cheng; Haiou Qu; Minglu Ma; Zhenhua Xu; Peng Xu; Yujie Fang; Tongwen Xu

doi:10.1016/j.ejmech.2006.12.035

Polyamidoamine (PAMAM) dendrimers as biocompatible carriers of quinolone antimicrobials: An in vitro study

Yiyun Cheng, Haiou Qu, Minglu Ma, Zhenhua Xu, Peng Xu, Yujie Fang, Tongwen Xu

University of Science and Technology of China

Research output: Contribution to journal › Article › peer-review

211 Scopus citations

Abstract

Quinolones, an expanding class of clinically established potent antibiotics, is not freely soluble in water which prevents the design of liquid dosage forms and restricts their use in topical applications. In the present study we investigated the potential of polyamidoamine (PAMAM) dendrimers as drug carriers of quinolones (nadifloxacin and prulifloxacin) by aqueous solubility and antibacterial activity studies. Results showed that the aqueous solubility of nadifloxacin and prulifloxacin was significantly increased by PAMAM dendrimers. Microbiology studies showed that nadifloxacin and prulifloxacin still exhibit their strong antimicrobial activities in the presence of dendrimers. These studies indicated that PAMAM dendrimers might be considered as biocompatible carriers of quinolones under suitable conditions.

Original language	English
Pages (from-to)	1032-1038
Number of pages	7
Journal	European Journal of Medicinal Chemistry
Volume	42
Issue number	7
DOIs	https://doi.org/10.1016/j.ejmech.2006.12.035
State	Published - Jul 2007
Externally published	Yes

Keywords

Antibacterial drugs
Drug carrier
Nadifloxacin
PAMAM
Polyamidoamine dendrimers
Prulifloxacin
Quinolones

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10.1016/j.ejmech.2006.12.035

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title = "Polyamidoamine (PAMAM) dendrimers as biocompatible carriers of quinolone antimicrobials: An in vitro study",

abstract = "Quinolones, an expanding class of clinically established potent antibiotics, is not freely soluble in water which prevents the design of liquid dosage forms and restricts their use in topical applications. In the present study we investigated the potential of polyamidoamine (PAMAM) dendrimers as drug carriers of quinolones (nadifloxacin and prulifloxacin) by aqueous solubility and antibacterial activity studies. Results showed that the aqueous solubility of nadifloxacin and prulifloxacin was significantly increased by PAMAM dendrimers. Microbiology studies showed that nadifloxacin and prulifloxacin still exhibit their strong antimicrobial activities in the presence of dendrimers. These studies indicated that PAMAM dendrimers might be considered as biocompatible carriers of quinolones under suitable conditions.",

keywords = "Antibacterial drugs, Drug carrier, Nadifloxacin, PAMAM, Polyamidoamine dendrimers, Prulifloxacin, Quinolones",

author = "Yiyun Cheng and Haiou Qu and Minglu Ma and Zhenhua Xu and Peng Xu and Yujie Fang and Tongwen Xu",

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doi = "10.1016/j.ejmech.2006.12.035",

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TY - JOUR

T1 - Polyamidoamine (PAMAM) dendrimers as biocompatible carriers of quinolone antimicrobials

T2 - An in vitro study

AU - Cheng, Yiyun

AU - Qu, Haiou

AU - Ma, Minglu

AU - Xu, Zhenhua

AU - Xu, Peng

AU - Fang, Yujie

AU - Xu, Tongwen

PY - 2007/7

Y1 - 2007/7

N2 - Quinolones, an expanding class of clinically established potent antibiotics, is not freely soluble in water which prevents the design of liquid dosage forms and restricts their use in topical applications. In the present study we investigated the potential of polyamidoamine (PAMAM) dendrimers as drug carriers of quinolones (nadifloxacin and prulifloxacin) by aqueous solubility and antibacterial activity studies. Results showed that the aqueous solubility of nadifloxacin and prulifloxacin was significantly increased by PAMAM dendrimers. Microbiology studies showed that nadifloxacin and prulifloxacin still exhibit their strong antimicrobial activities in the presence of dendrimers. These studies indicated that PAMAM dendrimers might be considered as biocompatible carriers of quinolones under suitable conditions.

AB - Quinolones, an expanding class of clinically established potent antibiotics, is not freely soluble in water which prevents the design of liquid dosage forms and restricts their use in topical applications. In the present study we investigated the potential of polyamidoamine (PAMAM) dendrimers as drug carriers of quinolones (nadifloxacin and prulifloxacin) by aqueous solubility and antibacterial activity studies. Results showed that the aqueous solubility of nadifloxacin and prulifloxacin was significantly increased by PAMAM dendrimers. Microbiology studies showed that nadifloxacin and prulifloxacin still exhibit their strong antimicrobial activities in the presence of dendrimers. These studies indicated that PAMAM dendrimers might be considered as biocompatible carriers of quinolones under suitable conditions.

KW - Antibacterial drugs

KW - Drug carrier

KW - Nadifloxacin

KW - PAMAM

KW - Polyamidoamine dendrimers

KW - Prulifloxacin

KW - Quinolones

UR - https://www.scopus.com/pages/publications/34250219583

U2 - 10.1016/j.ejmech.2006.12.035

DO - 10.1016/j.ejmech.2006.12.035

M3 - 文章

C2 - 17336426

AN - SCOPUS:34250219583

SN - 0223-5234

VL - 42

SP - 1032

EP - 1038

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

IS - 7

ER -

Polyamidoamine (PAMAM) dendrimers as biocompatible carriers of quinolone antimicrobials: An in vitro study

Abstract

Keywords

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