Poly(amidoamine) dendronized hollow fiber membranes: Synthesis, characterization, and preliminary applications as drug delivery devices

Qian Zhang; Na Wang; Tongwen Xu; Yiyun Cheng

doi:10.1016/j.actbio.2011.11.027

Poly(amidoamine) dendronized hollow fiber membranes: Synthesis, characterization, and preliminary applications as drug delivery devices

Qian Zhang
, Na Wang
, Tongwen Xu^*
, Yiyun Cheng

^*Corresponding author for this work

School of Life Sciences

University of Science and Technology of China

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Poly(amidoamine) (PAMAM) dendrons were prepared from hollow fiber membranes (HFM) consisting of bromomethylated poly(2,6-dimethyl-1,4-phenylene oxide) (BPPO) in a stepwise manner. The prepared HFM were characterized by Fourier transform infrared spectroscopy, elemental analysis, and scanning electron microscopy. The drug loading efficiency and release behavior of the PAMAM dendronized HFM were evaluated using sodium salicylate, sodium methotrexate, and Congo red as model drugs. The results suggest that PAMAM dendronized HFM can be effectively loaded with a variety of drugs and prolong the release of these drugs. The drug loading and release characteristics of the HFM depend on the generation of PAMAM dendrons grafted on the membranes. The prepared PAMAM dendronized BPPO HFM are promising scaffolds in drug delivery and tissue engineering.

Original language	English
Pages (from-to)	1316-1322
Number of pages	7
Journal	Acta Biomaterialia
Volume	8
Issue number	3
DOIs	https://doi.org/10.1016/j.actbio.2011.11.027
State	Published - Mar 2012

Keywords

Bromomethylated poly(2,6-dimethyl-1,4-phenylene oxide)
Dendrimer
Hollow fiber membrane
Hyperbranched
Poly(amidoamine)

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10.1016/j.actbio.2011.11.027

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@article{1680587904264ba7924cc88358da1d2e,

title = "Poly(amidoamine) dendronized hollow fiber membranes: Synthesis, characterization, and preliminary applications as drug delivery devices",

abstract = "Poly(amidoamine) (PAMAM) dendrons were prepared from hollow fiber membranes (HFM) consisting of bromomethylated poly(2,6-dimethyl-1,4-phenylene oxide) (BPPO) in a stepwise manner. The prepared HFM were characterized by Fourier transform infrared spectroscopy, elemental analysis, and scanning electron microscopy. The drug loading efficiency and release behavior of the PAMAM dendronized HFM were evaluated using sodium salicylate, sodium methotrexate, and Congo red as model drugs. The results suggest that PAMAM dendronized HFM can be effectively loaded with a variety of drugs and prolong the release of these drugs. The drug loading and release characteristics of the HFM depend on the generation of PAMAM dendrons grafted on the membranes. The prepared PAMAM dendronized BPPO HFM are promising scaffolds in drug delivery and tissue engineering.",

keywords = "Bromomethylated poly(2,6-dimethyl-1,4-phenylene oxide), Dendrimer, Hollow fiber membrane, Hyperbranched, Poly(amidoamine)",

author = "Qian Zhang and Na Wang and Tongwen Xu and Yiyun Cheng",

year = "2012",

month = mar,

doi = "10.1016/j.actbio.2011.11.027",

language = "英语",

volume = "8",

pages = "1316--1322",

journal = "Acta Biomaterialia",

issn = "1742-7061",

publisher = "Acta Materialia Inc",

number = "3",

}

TY - JOUR

T1 - Poly(amidoamine) dendronized hollow fiber membranes

T2 - Synthesis, characterization, and preliminary applications as drug delivery devices

AU - Zhang, Qian

AU - Wang, Na

AU - Xu, Tongwen

AU - Cheng, Yiyun

PY - 2012/3

Y1 - 2012/3

N2 - Poly(amidoamine) (PAMAM) dendrons were prepared from hollow fiber membranes (HFM) consisting of bromomethylated poly(2,6-dimethyl-1,4-phenylene oxide) (BPPO) in a stepwise manner. The prepared HFM were characterized by Fourier transform infrared spectroscopy, elemental analysis, and scanning electron microscopy. The drug loading efficiency and release behavior of the PAMAM dendronized HFM were evaluated using sodium salicylate, sodium methotrexate, and Congo red as model drugs. The results suggest that PAMAM dendronized HFM can be effectively loaded with a variety of drugs and prolong the release of these drugs. The drug loading and release characteristics of the HFM depend on the generation of PAMAM dendrons grafted on the membranes. The prepared PAMAM dendronized BPPO HFM are promising scaffolds in drug delivery and tissue engineering.

AB - Poly(amidoamine) (PAMAM) dendrons were prepared from hollow fiber membranes (HFM) consisting of bromomethylated poly(2,6-dimethyl-1,4-phenylene oxide) (BPPO) in a stepwise manner. The prepared HFM were characterized by Fourier transform infrared spectroscopy, elemental analysis, and scanning electron microscopy. The drug loading efficiency and release behavior of the PAMAM dendronized HFM were evaluated using sodium salicylate, sodium methotrexate, and Congo red as model drugs. The results suggest that PAMAM dendronized HFM can be effectively loaded with a variety of drugs and prolong the release of these drugs. The drug loading and release characteristics of the HFM depend on the generation of PAMAM dendrons grafted on the membranes. The prepared PAMAM dendronized BPPO HFM are promising scaffolds in drug delivery and tissue engineering.

KW - Bromomethylated poly(2,6-dimethyl-1,4-phenylene oxide)

KW - Dendrimer

KW - Hollow fiber membrane

KW - Hyperbranched

KW - Poly(amidoamine)

UR - https://www.scopus.com/pages/publications/84856521202

U2 - 10.1016/j.actbio.2011.11.027

DO - 10.1016/j.actbio.2011.11.027

M3 - 文章

C2 - 22154857

AN - SCOPUS:84856521202

SN - 1742-7061

VL - 8

SP - 1316

EP - 1322

JO - Acta Biomaterialia

JF - Acta Biomaterialia

IS - 3

ER -

Poly(amidoamine) dendronized hollow fiber membranes: Synthesis, characterization, and preliminary applications as drug delivery devices

Abstract

Keywords

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