Polyamidoamine dendrimers used as solubility enhancers of ketoprofen

Cheng Yiyun; Xu Tongwen; Fu Rongqiang

doi:10.1016/j.ejmech.2005.08.002

Polyamidoamine dendrimers used as solubility enhancers of ketoprofen

Cheng Yiyun^*
, Xu Tongwen
, Fu Rongqiang

^*Corresponding author for this work

University of Science and Technology of China

Research output: Contribution to journal › Article › peer-review

108 Scopus citations

Abstract

Ketoprofen is a non-steroidal anti-inflammatory drug which is not freely soluble in water and creates gastrointestinal problems. In the present study we investigated the potential of polyamidoamine (PAMAM) dendrimers to increase the solubility of ketoprofen. The effect of variables, such as pH condition, concentration and generation of dendrimer, has been investigated. The experimental results showed that the solubility of ketoprofen in the dendrimer solutions was proportional to dendrimer concentration. Under suitable conditions PAMAM dendrimers can be highly effective used to enhance the solubility of ketoprofen.

Original language	English
Pages (from-to)	1390-1393
Number of pages	4
Journal	European Journal of Medicinal Chemistry
Volume	40
Issue number	12
DOIs	https://doi.org/10.1016/j.ejmech.2005.08.002
State	Published - Dec 2005
Externally published	Yes

Keywords

Ketoprofen
PAMAM
Polyamidoamine dendrimers
Solubility enhancer

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10.1016/j.ejmech.2005.08.002

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title = "Polyamidoamine dendrimers used as solubility enhancers of ketoprofen",

abstract = "Ketoprofen is a non-steroidal anti-inflammatory drug which is not freely soluble in water and creates gastrointestinal problems. In the present study we investigated the potential of polyamidoamine (PAMAM) dendrimers to increase the solubility of ketoprofen. The effect of variables, such as pH condition, concentration and generation of dendrimer, has been investigated. The experimental results showed that the solubility of ketoprofen in the dendrimer solutions was proportional to dendrimer concentration. Under suitable conditions PAMAM dendrimers can be highly effective used to enhance the solubility of ketoprofen.",

keywords = "Ketoprofen, PAMAM, Polyamidoamine dendrimers, Solubility enhancer",

author = "Cheng Yiyun and Xu Tongwen and Fu Rongqiang",

year = "2005",

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doi = "10.1016/j.ejmech.2005.08.002",

language = "英语",

volume = "40",

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TY - JOUR

T1 - Polyamidoamine dendrimers used as solubility enhancers of ketoprofen

AU - Yiyun, Cheng

AU - Tongwen, Xu

AU - Rongqiang, Fu

PY - 2005/12

Y1 - 2005/12

N2 - Ketoprofen is a non-steroidal anti-inflammatory drug which is not freely soluble in water and creates gastrointestinal problems. In the present study we investigated the potential of polyamidoamine (PAMAM) dendrimers to increase the solubility of ketoprofen. The effect of variables, such as pH condition, concentration and generation of dendrimer, has been investigated. The experimental results showed that the solubility of ketoprofen in the dendrimer solutions was proportional to dendrimer concentration. Under suitable conditions PAMAM dendrimers can be highly effective used to enhance the solubility of ketoprofen.

AB - Ketoprofen is a non-steroidal anti-inflammatory drug which is not freely soluble in water and creates gastrointestinal problems. In the present study we investigated the potential of polyamidoamine (PAMAM) dendrimers to increase the solubility of ketoprofen. The effect of variables, such as pH condition, concentration and generation of dendrimer, has been investigated. The experimental results showed that the solubility of ketoprofen in the dendrimer solutions was proportional to dendrimer concentration. Under suitable conditions PAMAM dendrimers can be highly effective used to enhance the solubility of ketoprofen.

KW - Ketoprofen

KW - PAMAM

KW - Polyamidoamine dendrimers

KW - Solubility enhancer

UR - https://www.scopus.com/pages/publications/27744578025

U2 - 10.1016/j.ejmech.2005.08.002

DO - 10.1016/j.ejmech.2005.08.002

M3 - 文章

C2 - 16226353

AN - SCOPUS:27744578025

SN - 0223-5234

VL - 40

SP - 1390

EP - 1393

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

IS - 12

ER -

Polyamidoamine dendrimers used as solubility enhancers of ketoprofen

Abstract

Keywords

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