Abstract
A method based on plasmon resonance Rayleigh scattering (PRRS) spectroscopy and dark-field microscopy (DFM) was established for the real-time monitoring of a click reaction at the single-nanoparticle level. Click reactions on the surface of single gold nanoparticles (GNPs) result in interparticle coupling, which leads to a red-shift of the λmax (Δλ max=43nm) in the PRRS spectra and a color change of the single gold nanoparticles in DFM (from green to orange).
| Original language | English |
|---|---|
| Pages (from-to) | 6011-6014 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 52 |
| Issue number | 23 |
| DOIs | |
| State | Published - 3 Jun 2013 |
| Externally published | Yes |
Keywords
- click chemistry
- dark-field microscopy
- nanoparticles
- plasmon resonance scattering spectroscopy
- reaction monitoring