Phthalimide-based-SSCF3reagent for enantioselective dithiotrifluoromethylation

Wen Chao Gao; Jianrong Liu; Xuefeng Jiang

doi:10.1039/d1qo00001b

Phthalimide-based-SSCF₃reagent for enantioselective dithiotrifluoromethylation

Wen Chao Gao
, Jianrong Liu
, Xuefeng Jiang^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

An electrophilic phthalimide-based-SSCF3 reagent was designed and prepared for straightforward SSCF3 incorporation of diverse β-keto esters in natural products, pharmaceuticals and biological molecules. The asymmetric dithiotrifluoromethylation was achieved with a good to excellent enantioselectivity, catalyzed by a cinchona-alkaloid-based catalyst (DHQD)2PHAL via an ammonium-hydrogen-bonded induction mode.

Original language	English
Pages (from-to)	1275-1279
Number of pages	5
Journal	Organic Chemistry Frontiers
Volume	8
Issue number	6
DOIs	https://doi.org/10.1039/d1qo00001b
State	Published - 21 Mar 2021

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10.1039/d1qo00001b

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title = "Phthalimide-based-SSCF3reagent for enantioselective dithiotrifluoromethylation",

abstract = "An electrophilic phthalimide-based-SSCF3 reagent was designed and prepared for straightforward SSCF3 incorporation of diverse β-keto esters in natural products, pharmaceuticals and biological molecules. The asymmetric dithiotrifluoromethylation was achieved with a good to excellent enantioselectivity, catalyzed by a cinchona-alkaloid-based catalyst (DHQD)2PHAL via an ammonium-hydrogen-bonded induction mode.",

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AU - Gao, Wen Chao

AU - Liu, Jianrong

AU - Jiang, Xuefeng

PY - 2021/3/21

Y1 - 2021/3/21

N2 - An electrophilic phthalimide-based-SSCF3 reagent was designed and prepared for straightforward SSCF3 incorporation of diverse β-keto esters in natural products, pharmaceuticals and biological molecules. The asymmetric dithiotrifluoromethylation was achieved with a good to excellent enantioselectivity, catalyzed by a cinchona-alkaloid-based catalyst (DHQD)2PHAL via an ammonium-hydrogen-bonded induction mode.

AB - An electrophilic phthalimide-based-SSCF3 reagent was designed and prepared for straightforward SSCF3 incorporation of diverse β-keto esters in natural products, pharmaceuticals and biological molecules. The asymmetric dithiotrifluoromethylation was achieved with a good to excellent enantioselectivity, catalyzed by a cinchona-alkaloid-based catalyst (DHQD)2PHAL via an ammonium-hydrogen-bonded induction mode.

UR - https://www.scopus.com/pages/publications/85103107240

U2 - 10.1039/d1qo00001b

DO - 10.1039/d1qo00001b

M3 - 文章

AN - SCOPUS:85103107240

SN - 2052-4110

VL - 8

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EP - 1279

JO - Organic Chemistry Frontiers

JF - Organic Chemistry Frontiers

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ER -

Phthalimide-based-SSCF₃reagent for enantioselective dithiotrifluoromethylation

Abstract

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