Photolarvicidal effect of thienyl 1,3,4-thia(oxa)diazoles and their potential DNA photocleavage

Qingchun Huang; Ligang Liu; Ciying Xiao; Yufang Xu; Xuhong Qian

doi:10.1016/j.pestbp.2004.03.001

Photolarvicidal effect of thienyl 1,3,4-thia(oxa)diazoles and their potential DNA photocleavage

Qingchun Huang^*
, Ligang Liu
, Ciying Xiao
, Yufang Xu
, Xuhong Qian

^*Corresponding author for this work

East China University of Science and Technology
Dalian University of Technology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The photolarvicidal activities and DNA photocleavage effects of 10 thienyl 1,3,4-thia(oxa)diazoles were investigated. The compounds, as novel photosensitizers, showed strong larvicidal activities against Pseudaletia separata only under irradiated conditions. Thiadiazole containing Br atom (I₂) exhibited the highest photolarvicidal activity with mortality about 70.7%. The degree of mortality was increased with increasing accessibility period of the insects to photosensitizer-loaded leaves during exposure to light. The compounds also exhibited considerable DNA photocleavage activities on agarose gel electrophoresis that scissored supercoiled pBR322 DNA into two bands, scDNA and ocDNA. Oxadiazole containing Br atom (II₂) nicked pBR322 DNA to produce ocDNA with highest conversion about 76.21%. DTT decreased DNA photocleavage effects, but SOD increased photoactivities, in vitro. Br was important in improving the biofunctioning of the photosensitizers. These results demonstrate the potential mode of action of thienyl-thia(oxa)diazole photosensitizers as insecticidal agents.

Original language	English
Pages (from-to)	42-48
Number of pages	7
Journal	Pesticide Biochemistry and Physiology
Volume	79
Issue number	2
DOIs	https://doi.org/10.1016/j.pestbp.2004.03.001
State	Published - Jun 2004
Externally published	Yes

Keywords

DNA photocleavage
Photoactivated larvicidal activity
Thienyl 1,3,4-thia(oxa)diazoles

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10.1016/j.pestbp.2004.03.001

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@article{f0dc378bddef4acd884b8a9c21bf767b,

title = "Photolarvicidal effect of thienyl 1,3,4-thia(oxa)diazoles and their potential DNA photocleavage",

abstract = "The photolarvicidal activities and DNA photocleavage effects of 10 thienyl 1,3,4-thia(oxa)diazoles were investigated. The compounds, as novel photosensitizers, showed strong larvicidal activities against Pseudaletia separata only under irradiated conditions. Thiadiazole containing Br atom (I2) exhibited the highest photolarvicidal activity with mortality about 70.7\%. The degree of mortality was increased with increasing accessibility period of the insects to photosensitizer-loaded leaves during exposure to light. The compounds also exhibited considerable DNA photocleavage activities on agarose gel electrophoresis that scissored supercoiled pBR322 DNA into two bands, scDNA and ocDNA. Oxadiazole containing Br atom (II2) nicked pBR322 DNA to produce ocDNA with highest conversion about 76.21\%. DTT decreased DNA photocleavage effects, but SOD increased photoactivities, in vitro. Br was important in improving the biofunctioning of the photosensitizers. These results demonstrate the potential mode of action of thienyl-thia(oxa)diazole photosensitizers as insecticidal agents.",

keywords = "DNA photocleavage, Photoactivated larvicidal activity, Thienyl 1,3,4-thia(oxa)diazoles",

author = "Qingchun Huang and Ligang Liu and Ciying Xiao and Yufang Xu and Xuhong Qian",

year = "2004",

month = jun,

doi = "10.1016/j.pestbp.2004.03.001",

language = "英语",

volume = "79",

pages = "42--48",

journal = "Pesticide Biochemistry and Physiology",

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T1 - Photolarvicidal effect of thienyl 1,3,4-thia(oxa)diazoles and their potential DNA photocleavage

AU - Huang, Qingchun

AU - Liu, Ligang

AU - Xiao, Ciying

AU - Xu, Yufang

AU - Qian, Xuhong

PY - 2004/6

Y1 - 2004/6

N2 - The photolarvicidal activities and DNA photocleavage effects of 10 thienyl 1,3,4-thia(oxa)diazoles were investigated. The compounds, as novel photosensitizers, showed strong larvicidal activities against Pseudaletia separata only under irradiated conditions. Thiadiazole containing Br atom (I2) exhibited the highest photolarvicidal activity with mortality about 70.7%. The degree of mortality was increased with increasing accessibility period of the insects to photosensitizer-loaded leaves during exposure to light. The compounds also exhibited considerable DNA photocleavage activities on agarose gel electrophoresis that scissored supercoiled pBR322 DNA into two bands, scDNA and ocDNA. Oxadiazole containing Br atom (II2) nicked pBR322 DNA to produce ocDNA with highest conversion about 76.21%. DTT decreased DNA photocleavage effects, but SOD increased photoactivities, in vitro. Br was important in improving the biofunctioning of the photosensitizers. These results demonstrate the potential mode of action of thienyl-thia(oxa)diazole photosensitizers as insecticidal agents.

AB - The photolarvicidal activities and DNA photocleavage effects of 10 thienyl 1,3,4-thia(oxa)diazoles were investigated. The compounds, as novel photosensitizers, showed strong larvicidal activities against Pseudaletia separata only under irradiated conditions. Thiadiazole containing Br atom (I2) exhibited the highest photolarvicidal activity with mortality about 70.7%. The degree of mortality was increased with increasing accessibility period of the insects to photosensitizer-loaded leaves during exposure to light. The compounds also exhibited considerable DNA photocleavage activities on agarose gel electrophoresis that scissored supercoiled pBR322 DNA into two bands, scDNA and ocDNA. Oxadiazole containing Br atom (II2) nicked pBR322 DNA to produce ocDNA with highest conversion about 76.21%. DTT decreased DNA photocleavage effects, but SOD increased photoactivities, in vitro. Br was important in improving the biofunctioning of the photosensitizers. These results demonstrate the potential mode of action of thienyl-thia(oxa)diazole photosensitizers as insecticidal agents.

KW - DNA photocleavage

KW - Photoactivated larvicidal activity

KW - Thienyl 1,3,4-thia(oxa)diazoles

UR - https://www.scopus.com/pages/publications/2942525756

U2 - 10.1016/j.pestbp.2004.03.001

DO - 10.1016/j.pestbp.2004.03.001

M3 - 文章

AN - SCOPUS:2942525756

SN - 0048-3575

VL - 79

SP - 42

EP - 48

JO - Pesticide Biochemistry and Physiology

JF - Pesticide Biochemistry and Physiology

IS - 2

ER -

Photolarvicidal effect of thienyl 1,3,4-thia(oxa)diazoles and their potential DNA photocleavage

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Keywords

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