Photoinduced Diazo Carbene-Promoted C(sp3)-H Oxidative Cross-Coupling Reaction for α-Triazolation of Isochromans

Tang Xiao; Jinhua Liu; Xiang Wu; Shunying Liu

doi:10.1021/acs.joc.4c02722

Photoinduced Diazo Carbene-Promoted C(sp³)-H Oxidative Cross-Coupling Reaction for α-Triazolation of Isochromans

Tang Xiao
, Jinhua Liu
, Xiang Wu
, Shunying Liu^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China Normal University

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A photocatalytic diazo triplet carbene-promoted C(sp³)-H oxidative coupling of isochromans and triazoles was developed in up to 83% yield at room temperature in air. The radical-like triplet carbenes were used as efficient HAT acceptors, and the possible synergistic HAT enabled the unprecedented process with a high regioselectivity.

Original language	English
Pages (from-to)	4202-4208
Number of pages	7
Journal	Journal of Organic Chemistry
Volume	90
Issue number	12
DOIs	https://doi.org/10.1021/acs.joc.4c02722
State	Published - 28 Mar 2025

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10.1021/acs.joc.4c02722

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title = "Photoinduced Diazo Carbene-Promoted C(sp3)-H Oxidative Cross-Coupling Reaction for α-Triazolation of Isochromans",

abstract = "A photocatalytic diazo triplet carbene-promoted C(sp3)-H oxidative coupling of isochromans and triazoles was developed in up to 83\% yield at room temperature in air. The radical-like triplet carbenes were used as efficient HAT acceptors, and the possible synergistic HAT enabled the unprecedented process with a high regioselectivity.",

author = "Tang Xiao and Jinhua Liu and Xiang Wu and Shunying Liu",

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doi = "10.1021/acs.joc.4c02722",

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T1 - Photoinduced Diazo Carbene-Promoted C(sp3)-H Oxidative Cross-Coupling Reaction for α-Triazolation of Isochromans

AU - Xiao, Tang

AU - Liu, Jinhua

AU - Wu, Xiang

AU - Liu, Shunying

PY - 2025/3/28

Y1 - 2025/3/28

N2 - A photocatalytic diazo triplet carbene-promoted C(sp3)-H oxidative coupling of isochromans and triazoles was developed in up to 83% yield at room temperature in air. The radical-like triplet carbenes were used as efficient HAT acceptors, and the possible synergistic HAT enabled the unprecedented process with a high regioselectivity.

AB - A photocatalytic diazo triplet carbene-promoted C(sp3)-H oxidative coupling of isochromans and triazoles was developed in up to 83% yield at room temperature in air. The radical-like triplet carbenes were used as efficient HAT acceptors, and the possible synergistic HAT enabled the unprecedented process with a high regioselectivity.

UR - https://www.scopus.com/pages/publications/105001471819

U2 - 10.1021/acs.joc.4c02722

DO - 10.1021/acs.joc.4c02722

M3 - 文章

AN - SCOPUS:105001471819

SN - 0022-3263

VL - 90

SP - 4202

EP - 4208

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 12

ER -

Photoinduced Diazo Carbene-Promoted C(sp³)-H Oxidative Cross-Coupling Reaction for α-Triazolation of Isochromans

Abstract

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