Photodriven Site-Selective Deuteration of Pyridyl Ketones with Deuterium Oxide

Wen Qiang Tian; Chaoren Shen; Yanzhong Li; Kaiwu Dong

doi:10.1055/a-2509-0121

Photodriven Site-Selective Deuteration of Pyridyl Ketones with Deuterium Oxide

Wen Qiang Tian
, Chaoren Shen
, Yanzhong Li^*
, Kaiwu Dong^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China Normal University

Research output: Contribution to journal › Article › peer-review

Abstract

In this work, a photodriven phosphine/D ₂ O-mediated method for the reductive deuteration of pyridyl ketones was developed. By regulating the reaction conditions, site-selective deuteration of pyridyl diketones was achieved with high deuterium-incorporation rates.

Original language	English
Pages (from-to)	1242-1246
Number of pages	5
Journal	Synlett
Volume	36
Issue number	9
DOIs	https://doi.org/10.1055/a-2509-0121
State	Published - 5 Feb 2025

Keywords

deuteration
deuterium oxide
photocatalysis
pyridyl ketones
site selectivity

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10.1055/a-2509-0121

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title = "Photodriven Site-Selective Deuteration of Pyridyl Ketones with Deuterium Oxide",

abstract = "In this work, a photodriven phosphine/D 2 O-mediated method for the reductive deuteration of pyridyl ketones was developed. By regulating the reaction conditions, site-selective deuteration of pyridyl diketones was achieved with high deuterium-incorporation rates.",

keywords = "deuteration, deuterium oxide, photocatalysis, pyridyl ketones, site selectivity",

author = "Tian, \{Wen Qiang\} and Chaoren Shen and Yanzhong Li and Kaiwu Dong",

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doi = "10.1055/a-2509-0121",

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T1 - Photodriven Site-Selective Deuteration of Pyridyl Ketones with Deuterium Oxide

AU - Tian, Wen Qiang

AU - Shen, Chaoren

AU - Li, Yanzhong

AU - Dong, Kaiwu

PY - 2025/2/5

Y1 - 2025/2/5

N2 - In this work, a photodriven phosphine/D 2 O-mediated method for the reductive deuteration of pyridyl ketones was developed. By regulating the reaction conditions, site-selective deuteration of pyridyl diketones was achieved with high deuterium-incorporation rates.

AB - In this work, a photodriven phosphine/D 2 O-mediated method for the reductive deuteration of pyridyl ketones was developed. By regulating the reaction conditions, site-selective deuteration of pyridyl diketones was achieved with high deuterium-incorporation rates.

KW - deuteration

KW - deuterium oxide

KW - photocatalysis

KW - pyridyl ketones

KW - site selectivity

UR - https://www.scopus.com/pages/publications/85217579224

U2 - 10.1055/a-2509-0121

DO - 10.1055/a-2509-0121

M3 - 文章

AN - SCOPUS:85217579224

SN - 0936-5214

VL - 36

SP - 1242

EP - 1246

JO - Synlett

JF - Synlett

IS - 9

ER -

Photodriven Site-Selective Deuteration of Pyridyl Ketones with Deuterium Oxide

Abstract

Keywords

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