Photocalibrated NO Release from N-Nitrosated Napthalimides upon One-Photon or Two-Photon Irradiation

Ziqian Zhang; Jiayao Wu; Zhihao Shang; Chao Wang; Jiagao Cheng; Xuhong Qian; Yi Xiao; Zhiping Xu; Youjun Yang

doi:10.1021/acs.analchem.6b01603

Photocalibrated NO Release from N-Nitrosated Napthalimides upon One-Photon or Two-Photon Irradiation

Ziqian Zhang, Jiayao Wu, Zhihao Shang, Chao Wang, Jiagao Cheng, Xuhong Qian, Yi Xiao^*, Zhiping Xu, Youjun Yang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

82 Scopus citations

Abstract

NO donors are routinely used as the exogenous source in in vitro studies. However, the kinetics or the dose of NO release from the existing donors is not readily monitored. This complicates the elucidation of the involvement of NO in a biological response. We report herein a series of NO donors (NOD545a-g), whose NO release is triggered by UV light at 365 nm or a two-photon laser at 740 nm, and importantly, their NO release is accompanied by a drastic fluorescence turn-on, which has been harnessed to follow the kinetics and dose of NO release in a real-time fashion with spectroscopic methods or microscopic methods in in vitro studies. These merits have rendered NOD545a-g useful molecular tools in NO biology.

Original language	English
Pages (from-to)	7274-7280
Number of pages	7
Journal	Analytical Chemistry
Volume	88
Issue number	14
DOIs	https://doi.org/10.1021/acs.analchem.6b01603
State	Published - 19 Jul 2016
Externally published	Yes

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title = "Photocalibrated NO Release from N-Nitrosated Napthalimides upon One-Photon or Two-Photon Irradiation",

abstract = "NO donors are routinely used as the exogenous source in in vitro studies. However, the kinetics or the dose of NO release from the existing donors is not readily monitored. This complicates the elucidation of the involvement of NO in a biological response. We report herein a series of NO donors (NOD545a-g), whose NO release is triggered by UV light at 365 nm or a two-photon laser at 740 nm, and importantly, their NO release is accompanied by a drastic fluorescence turn-on, which has been harnessed to follow the kinetics and dose of NO release in a real-time fashion with spectroscopic methods or microscopic methods in in vitro studies. These merits have rendered NOD545a-g useful molecular tools in NO biology.",

author = "Ziqian Zhang and Jiayao Wu and Zhihao Shang and Chao Wang and Jiagao Cheng and Xuhong Qian and Yi Xiao and Zhiping Xu and Youjun Yang",

note = "Publisher Copyright: {\textcopyright} 2016 American Chemical Society.",

year = "2016",

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day = "19",

doi = "10.1021/acs.analchem.6b01603",

language = "英语",

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T1 - Photocalibrated NO Release from N-Nitrosated Napthalimides upon One-Photon or Two-Photon Irradiation

AU - Zhang, Ziqian

AU - Wu, Jiayao

AU - Shang, Zhihao

AU - Wang, Chao

AU - Cheng, Jiagao

AU - Qian, Xuhong

AU - Xiao, Yi

AU - Xu, Zhiping

AU - Yang, Youjun

PY - 2016/7/19

Y1 - 2016/7/19

N2 - NO donors are routinely used as the exogenous source in in vitro studies. However, the kinetics or the dose of NO release from the existing donors is not readily monitored. This complicates the elucidation of the involvement of NO in a biological response. We report herein a series of NO donors (NOD545a-g), whose NO release is triggered by UV light at 365 nm or a two-photon laser at 740 nm, and importantly, their NO release is accompanied by a drastic fluorescence turn-on, which has been harnessed to follow the kinetics and dose of NO release in a real-time fashion with spectroscopic methods or microscopic methods in in vitro studies. These merits have rendered NOD545a-g useful molecular tools in NO biology.

AB - NO donors are routinely used as the exogenous source in in vitro studies. However, the kinetics or the dose of NO release from the existing donors is not readily monitored. This complicates the elucidation of the involvement of NO in a biological response. We report herein a series of NO donors (NOD545a-g), whose NO release is triggered by UV light at 365 nm or a two-photon laser at 740 nm, and importantly, their NO release is accompanied by a drastic fluorescence turn-on, which has been harnessed to follow the kinetics and dose of NO release in a real-time fashion with spectroscopic methods or microscopic methods in in vitro studies. These merits have rendered NOD545a-g useful molecular tools in NO biology.

UR - https://www.scopus.com/pages/publications/84978924524

U2 - 10.1021/acs.analchem.6b01603

DO - 10.1021/acs.analchem.6b01603

M3 - 文章

AN - SCOPUS:84978924524

SN - 0003-2700

VL - 88

SP - 7274

EP - 7280

JO - Analytical Chemistry

JF - Analytical Chemistry

IS - 14

ER -

Photocalibrated NO Release from N-Nitrosated Napthalimides upon One-Photon or Two-Photon Irradiation

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