Phosphine-catalyzed conjugate cyanation of β-trifluoromethyl enones: Access to α-trifluoromethyl γ-carbonyl nitriles

Tao Zhou; Xin Ji; Junliang Zhang; Lu Liu

doi:10.1039/d0qo00582g

Phosphine-catalyzed conjugate cyanation of β-trifluoromethyl enones: Access to α-trifluoromethyl γ-carbonyl nitriles

Tao Zhou, Xin Ji, Junliang Zhang, Lu Liu

School of Chemistry and Molecular Engineering

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Herein, we developed an efficient conjugate cyanation of β-trifluoromethyl enones with TMSCN mediated by phosphine. In this transformation, the key organophosphorus zwitterion, which was generated in situ by mixing organophosphine with methyl acrylate, could enable this transformation as a highly efficient Lewis base catalyst.

Original language	English
Pages (from-to)	2644-2648
Number of pages	5
Journal	Organic Chemistry Frontiers
Volume	7
Issue number	18
DOIs	https://doi.org/10.1039/d0qo00582g
State	Published - 21 Sep 2020

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title = "Phosphine-catalyzed conjugate cyanation of β-trifluoromethyl enones: Access to α-trifluoromethyl γ-carbonyl nitriles",

abstract = "Herein, we developed an efficient conjugate cyanation of β-trifluoromethyl enones with TMSCN mediated by phosphine. In this transformation, the key organophosphorus zwitterion, which was generated in situ by mixing organophosphine with methyl acrylate, could enable this transformation as a highly efficient Lewis base catalyst.",

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T1 - Phosphine-catalyzed conjugate cyanation of β-trifluoromethyl enones

T2 - Access to α-trifluoromethyl γ-carbonyl nitriles

AU - Zhou, Tao

AU - Ji, Xin

AU - Zhang, Junliang

AU - Liu, Lu

PY - 2020/9/21

Y1 - 2020/9/21

N2 - Herein, we developed an efficient conjugate cyanation of β-trifluoromethyl enones with TMSCN mediated by phosphine. In this transformation, the key organophosphorus zwitterion, which was generated in situ by mixing organophosphine with methyl acrylate, could enable this transformation as a highly efficient Lewis base catalyst.

AB - Herein, we developed an efficient conjugate cyanation of β-trifluoromethyl enones with TMSCN mediated by phosphine. In this transformation, the key organophosphorus zwitterion, which was generated in situ by mixing organophosphine with methyl acrylate, could enable this transformation as a highly efficient Lewis base catalyst.

UR - https://www.scopus.com/pages/publications/85093512158

U2 - 10.1039/d0qo00582g

DO - 10.1039/d0qo00582g

M3 - 文章

AN - SCOPUS:85093512158

SN - 2052-4110

VL - 7

SP - 2644

EP - 2648

JO - Organic Chemistry Frontiers

JF - Organic Chemistry Frontiers

IS - 18

ER -

Phosphine-catalyzed conjugate cyanation of β-trifluoromethyl enones: Access to α-trifluoromethyl γ-carbonyl nitriles

Abstract

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