Phosphine-Catalyzed [3 + 2] Cycloaddition Reaction of α-Diazoacetates and β-Trifluoromethyl Enones: A Facile Access to Multisubstituted 4-(Trifluoromethyl)pyrazolines

Yongfeng Li; Huamin Wang; Yuwei Su; Runchen Li; Cao Li; Lu Liu; Junliang Zhang

doi:10.1021/acs.orglett.8b02757

Phosphine-Catalyzed [3 + 2] Cycloaddition Reaction of α-Diazoacetates and β-Trifluoromethyl Enones: A Facile Access to Multisubstituted 4-(Trifluoromethyl)pyrazolines

Yongfeng Li
, Huamin Wang
, Yuwei Su
, Runchen Li
, Cao Li
, Lu Liu^*
, Junliang Zhang

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China Normal University

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

A novel phosphine-catalyzed [3 + 2] cycloaddition of α-diazoacetates and β-trifluoromethyl enones has been developed that provides facile access to multisubstituted 4-(trifluoromethyl)pyrazolines in good to excellent yields at room temperature. In addition, a tandem [3 + 2] cycloaddition/Michael addition is also presented.

Original language	English
Pages (from-to)	6444-6448
Number of pages	5
Journal	Organic Letters
Volume	20
Issue number	20
DOIs	https://doi.org/10.1021/acs.orglett.8b02757
State	Published - 19 Oct 2018

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title = "Phosphine-Catalyzed [3 + 2] Cycloaddition Reaction of α-Diazoacetates and β-Trifluoromethyl Enones: A Facile Access to Multisubstituted 4-(Trifluoromethyl)pyrazolines",

abstract = "A novel phosphine-catalyzed [3 + 2] cycloaddition of α-diazoacetates and β-trifluoromethyl enones has been developed that provides facile access to multisubstituted 4-(trifluoromethyl)pyrazolines in good to excellent yields at room temperature. In addition, a tandem [3 + 2] cycloaddition/Michael addition is also presented.",

author = "Yongfeng Li and Huamin Wang and Yuwei Su and Runchen Li and Cao Li and Lu Liu and Junliang Zhang",

note = "Publisher Copyright: {\textcopyright} 2018 American Chemical Society.",

year = "2018",

month = oct,

day = "19",

doi = "10.1021/acs.orglett.8b02757",

language = "英语",

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TY - JOUR

T1 - Phosphine-Catalyzed [3 + 2] Cycloaddition Reaction of α-Diazoacetates and β-Trifluoromethyl Enones

T2 - A Facile Access to Multisubstituted 4-(Trifluoromethyl)pyrazolines

AU - Li, Yongfeng

AU - Wang, Huamin

AU - Su, Yuwei

AU - Li, Runchen

AU - Li, Cao

AU - Liu, Lu

AU - Zhang, Junliang

PY - 2018/10/19

Y1 - 2018/10/19

N2 - A novel phosphine-catalyzed [3 + 2] cycloaddition of α-diazoacetates and β-trifluoromethyl enones has been developed that provides facile access to multisubstituted 4-(trifluoromethyl)pyrazolines in good to excellent yields at room temperature. In addition, a tandem [3 + 2] cycloaddition/Michael addition is also presented.

AB - A novel phosphine-catalyzed [3 + 2] cycloaddition of α-diazoacetates and β-trifluoromethyl enones has been developed that provides facile access to multisubstituted 4-(trifluoromethyl)pyrazolines in good to excellent yields at room temperature. In addition, a tandem [3 + 2] cycloaddition/Michael addition is also presented.

UR - https://www.scopus.com/pages/publications/85054552503

U2 - 10.1021/acs.orglett.8b02757

DO - 10.1021/acs.orglett.8b02757

M3 - 文章

C2 - 30277401

AN - SCOPUS:85054552503

SN - 1523-7060

VL - 20

SP - 6444

EP - 6448

JO - Organic Letters

JF - Organic Letters

IS - 20

ER -

Phosphine-Catalyzed [3 + 2] Cycloaddition Reaction of α-Diazoacetates and β-Trifluoromethyl Enones: A Facile Access to Multisubstituted 4-(Trifluoromethyl)pyrazolines

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