PH-Operated Triplex DNA Device on MoS                         2                          Nanosheets

Wei Ji; Dan Li; Wei Lai; Xiaowei Yao; Md Fazle Alam; Weijia Zhang; Hao Pei; Li Li; Arun Richard Chandrasekaran

doi:10.1021/acs.langmuir.8b04272

PH-Operated Triplex DNA Device on MoS ₂ Nanosheets

Wei Ji
, Dan Li
, Wei Lai
, Xiaowei Yao
, Md Fazle Alam
, Weijia Zhang
, Hao Pei
, Li Li^*
, Arun Richard Chandrasekaran

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

We report a triplex-based DNA device coupled with molybdenum disulfide (MoS ₂ ) nanosheets for use as a pH-sensing platform. The device transitions from a duplex state at pH 8 to a triplex state at pH 5. The interaction of the device with MoS ₂ nanosheets in the two states is read out as a fluorescence signal from a pH-insensitive dye attached to the device. We characterized the operation of the DNA device on MoS ₂ nanosheets, analyzed the pH response, and tested the reversibility of the system. Our strategy can lead to the creation of a suite of biosensors where the sensing element is a triplex DNA device and the signal response is modulated by inorganic nanomaterials.

Original language	English
Pages (from-to)	5050-5053
Number of pages	4
Journal	Langmuir
Volume	35
Issue number	14
DOIs	https://doi.org/10.1021/acs.langmuir.8b04272
State	Published - 9 Apr 2019

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title = " PH-Operated Triplex DNA Device on MoS 2 Nanosheets ",

abstract = " We report a triplex-based DNA device coupled with molybdenum disulfide (MoS 2 ) nanosheets for use as a pH-sensing platform. The device transitions from a duplex state at pH 8 to a triplex state at pH 5. The interaction of the device with MoS 2 nanosheets in the two states is read out as a fluorescence signal from a pH-insensitive dye attached to the device. We characterized the operation of the DNA device on MoS 2 nanosheets, analyzed the pH response, and tested the reversibility of the system. Our strategy can lead to the creation of a suite of biosensors where the sensing element is a triplex DNA device and the signal response is modulated by inorganic nanomaterials.",

author = "Wei Ji and Dan Li and Wei Lai and Xiaowei Yao and Alam, \{Md Fazle\} and Weijia Zhang and Hao Pei and Li Li and Chandrasekaran, \{Arun Richard\}",

note = "Publisher Copyright: {\textcopyright} 2019 American Chemical Society.",

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doi = "10.1021/acs.langmuir.8b04272",

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T1 - PH-Operated Triplex DNA Device on MoS 2 Nanosheets

AU - Ji, Wei

AU - Li, Dan

AU - Lai, Wei

AU - Yao, Xiaowei

AU - Alam, Md Fazle

AU - Zhang, Weijia

AU - Pei, Hao

AU - Li, Li

AU - Chandrasekaran, Arun Richard

PY - 2019/4/9

Y1 - 2019/4/9

N2 - We report a triplex-based DNA device coupled with molybdenum disulfide (MoS 2 ) nanosheets for use as a pH-sensing platform. The device transitions from a duplex state at pH 8 to a triplex state at pH 5. The interaction of the device with MoS 2 nanosheets in the two states is read out as a fluorescence signal from a pH-insensitive dye attached to the device. We characterized the operation of the DNA device on MoS 2 nanosheets, analyzed the pH response, and tested the reversibility of the system. Our strategy can lead to the creation of a suite of biosensors where the sensing element is a triplex DNA device and the signal response is modulated by inorganic nanomaterials.

AB - We report a triplex-based DNA device coupled with molybdenum disulfide (MoS 2 ) nanosheets for use as a pH-sensing platform. The device transitions from a duplex state at pH 8 to a triplex state at pH 5. The interaction of the device with MoS 2 nanosheets in the two states is read out as a fluorescence signal from a pH-insensitive dye attached to the device. We characterized the operation of the DNA device on MoS 2 nanosheets, analyzed the pH response, and tested the reversibility of the system. Our strategy can lead to the creation of a suite of biosensors where the sensing element is a triplex DNA device and the signal response is modulated by inorganic nanomaterials.

UR - https://www.scopus.com/pages/publications/85064202726

U2 - 10.1021/acs.langmuir.8b04272

DO - 10.1021/acs.langmuir.8b04272

M3 - 文章

C2 - 30879305

AN - SCOPUS:85064202726

SN - 0743-7463

VL - 35

SP - 5050

EP - 5053

JO - Langmuir

JF - Langmuir

IS - 14

ER -

PH-Operated Triplex DNA Device on MoS ₂ Nanosheets

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