TY - JOUR
T1 - Peroxisome proliferator-activated receptors and renal diseases
AU - Wu, Jing
AU - Chen, Lihong
AU - Zhang, Dongjuan
AU - Huo, Ming
AU - Zhang, Xiaoyan
AU - Pu, Dan
AU - Guan, Youfei
PY - 2009/1/1
Y1 - 2009/1/1
N2 - Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligand-dependent transcription factors. Three isoforms of PPAR, i.e., PPAR-α, -δ, and -γ, have been identified and are differentially expressed in various tissues, including the kidney. The target genes of PPARs are involved in diverse biological processes, including adipogenesis, lipid metabolism, insulin sensitivity, inflammatory response, reproduction, and cell growth and differentiation. PPARs have been reported to protect against renal injury through indirect systemic effects and/or direct renal effects in diabetic nephropathy, glomerulonephritis, renal cell carcinoma, acute renal failure and chronic renal disease. In this review, we summarize the role of the three identified PPAR isoforms, PPARα, -δ, and -γ, in renal physiology and discuss the renoprotective effects of PPAR ligands in various kidney diseases.
AB - Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligand-dependent transcription factors. Three isoforms of PPAR, i.e., PPAR-α, -δ, and -γ, have been identified and are differentially expressed in various tissues, including the kidney. The target genes of PPARs are involved in diverse biological processes, including adipogenesis, lipid metabolism, insulin sensitivity, inflammatory response, reproduction, and cell growth and differentiation. PPARs have been reported to protect against renal injury through indirect systemic effects and/or direct renal effects in diabetic nephropathy, glomerulonephritis, renal cell carcinoma, acute renal failure and chronic renal disease. In this review, we summarize the role of the three identified PPAR isoforms, PPARα, -δ, and -γ, in renal physiology and discuss the renoprotective effects of PPAR ligands in various kidney diseases.
KW - Diabetic nephropathy
KW - Fibrate
KW - Ppars
KW - Renal disease
KW - Renoprotection
KW - Review
KW - Tzd
UR - https://www.scopus.com/pages/publications/63849221855
U2 - 10.2741/3291
DO - 10.2741/3291
M3 - 文章
C2 - 19273113
AN - SCOPUS:63849221855
SN - 2768-6701
VL - 14
SP - 995
EP - 1009
JO - Frontiers in Bioscience - Landmark
JF - Frontiers in Bioscience - Landmark
IS - 3
ER -
