Abstract
Peroxisome proliferator-activated receptor α (PPARα) plays a key role in lipid metabolism and glucose homeostasis and a crucial role in the prevention and treatment of metabolic diseases. Natural dietary compounds, including nutrients and phytochemicals, are PPARα ligands or modulators. High-throughput screening assays have been developed to screen for PPARα ligands and modulators in our diet. In the present review, we discuss recent advances in our knowledge of PPARα, including its structure, function, and ligand and modulator screening assays, and summarize the different types of dietary PPARα ligands and modulators.
| Original language | English |
|---|---|
| Pages (from-to) | 341-352 |
| Number of pages | 12 |
| Journal | Journal of Diabetes |
| Volume | 9 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1 Apr 2017 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- diet
- ligand
- modulator
- peroxisome proliferator-activated receptor α
- screening methods
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