Peptide p3 may play a neuroprotective role in the brain

Wenfei Han; Tingting Ji; Bing Mei; Jiansheng Su

doi:10.1016/j.mehy.2010.12.013

Peptide p3 may play a neuroprotective role in the brain

Wenfei Han
, Tingting Ji
, Bing Mei^*
, Jiansheng Su

^*Corresponding author for this work

School of Psychology and Cognitive Science

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Alzheimer's disease (AD) is an age-related neurodegenerative disease. The amyloid-β (Aβ) peptide is considered a major etiological factor in the development of AD. BACE1-deficient mice and forebrain-specific conditional presenilin1 and presenilin2 double knockout mice (presenilins cDKO mice) both lack Aβ, but exhibit completely different phenotypes. The peptide p3 may play a neuroprotective role. A lack of peptide p3 could trigger an inflammatory response in the brain of presenilins cDKO mice.

Original language	English
Pages (from-to)	543-546
Number of pages	4
Journal	Medical Hypotheses
Volume	76
Issue number	4
DOIs	https://doi.org/10.1016/j.mehy.2010.12.013
State	Published - Apr 2011

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abstract = "Alzheimer's disease (AD) is an age-related neurodegenerative disease. The amyloid-β (Aβ) peptide is considered a major etiological factor in the development of AD. BACE1-deficient mice and forebrain-specific conditional presenilin1 and presenilin2 double knockout mice (presenilins cDKO mice) both lack Aβ, but exhibit completely different phenotypes. The peptide p3 may play a neuroprotective role. A lack of peptide p3 could trigger an inflammatory response in the brain of presenilins cDKO mice.",

author = "Wenfei Han and Tingting Ji and Bing Mei and Jiansheng Su",

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N2 - Alzheimer's disease (AD) is an age-related neurodegenerative disease. The amyloid-β (Aβ) peptide is considered a major etiological factor in the development of AD. BACE1-deficient mice and forebrain-specific conditional presenilin1 and presenilin2 double knockout mice (presenilins cDKO mice) both lack Aβ, but exhibit completely different phenotypes. The peptide p3 may play a neuroprotective role. A lack of peptide p3 could trigger an inflammatory response in the brain of presenilins cDKO mice.

AB - Alzheimer's disease (AD) is an age-related neurodegenerative disease. The amyloid-β (Aβ) peptide is considered a major etiological factor in the development of AD. BACE1-deficient mice and forebrain-specific conditional presenilin1 and presenilin2 double knockout mice (presenilins cDKO mice) both lack Aβ, but exhibit completely different phenotypes. The peptide p3 may play a neuroprotective role. A lack of peptide p3 could trigger an inflammatory response in the brain of presenilins cDKO mice.

UR - https://www.scopus.com/pages/publications/79952313805

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DO - 10.1016/j.mehy.2010.12.013

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JO - Medical Hypotheses

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Peptide p3 may play a neuroprotective role in the brain

Abstract

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