Pd(II)-catalyzed intramolecular 1,2-aminoalkylation of conjugated 1,3-dienes for the synthesis of pyrrolizidines

Dong Xing; Dan Yang

doi:10.1021/ol401901h

Pd(II)-catalyzed intramolecular 1,2-aminoalkylation of conjugated 1,3-dienes for the synthesis of pyrrolizidines

Dong Xing
, Dan Yang^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

The University of Hong Kong

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

A palladium(II)-catalyzed tandem cyclization reaction involving an intramolecular 1,2-aminoalkylation of N-4,6-dienyl β-keto amides has been developed. This process provides an efficient method for the rapid assembly of pyrrolizidines starting from linear substrates in moderate to good yields and high to excellent diastereoselectivities.

Original language	English
Pages (from-to)	4370-4373
Number of pages	4
Journal	Organic Letters
Volume	15
Issue number	17
DOIs	https://doi.org/10.1021/ol401901h
State	Published - 6 Sep 2013

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10.1021/ol401901h

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title = "Pd(II)-catalyzed intramolecular 1,2-aminoalkylation of conjugated 1,3-dienes for the synthesis of pyrrolizidines",

abstract = "A palladium(II)-catalyzed tandem cyclization reaction involving an intramolecular 1,2-aminoalkylation of N-4,6-dienyl β-keto amides has been developed. This process provides an efficient method for the rapid assembly of pyrrolizidines starting from linear substrates in moderate to good yields and high to excellent diastereoselectivities.",

author = "Dong Xing and Dan Yang",

year = "2013",

month = sep,

day = "6",

doi = "10.1021/ol401901h",

language = "英语",

volume = "15",

pages = "4370--4373",

journal = "Organic Letters",

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T1 - Pd(II)-catalyzed intramolecular 1,2-aminoalkylation of conjugated 1,3-dienes for the synthesis of pyrrolizidines

AU - Xing, Dong

AU - Yang, Dan

PY - 2013/9/6

Y1 - 2013/9/6

N2 - A palladium(II)-catalyzed tandem cyclization reaction involving an intramolecular 1,2-aminoalkylation of N-4,6-dienyl β-keto amides has been developed. This process provides an efficient method for the rapid assembly of pyrrolizidines starting from linear substrates in moderate to good yields and high to excellent diastereoselectivities.

AB - A palladium(II)-catalyzed tandem cyclization reaction involving an intramolecular 1,2-aminoalkylation of N-4,6-dienyl β-keto amides has been developed. This process provides an efficient method for the rapid assembly of pyrrolizidines starting from linear substrates in moderate to good yields and high to excellent diastereoselectivities.

UR - https://www.scopus.com/pages/publications/84883799270

U2 - 10.1021/ol401901h

DO - 10.1021/ol401901h

M3 - 文章

C2 - 23980544

AN - SCOPUS:84883799270

SN - 1523-7060

VL - 15

SP - 4370

EP - 4373

JO - Organic Letters

JF - Organic Letters

IS - 17

ER -

Pd(II)-catalyzed intramolecular 1,2-aminoalkylation of conjugated 1,3-dienes for the synthesis of pyrrolizidines

Abstract

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