Pd-catalyzed hydroaminocarbonylation of alkynes with aliphatic amines and its mechanism study

This work describes the hydroaminocarbonylation of alkynes with aliphatic amines without the addition of any acid additive. Excellent conversion and regioselectivity toward the formation of branched amides were obtained over a dppp-based Pd-catalytic system. The catalytic mechanism was studied and disclosed that the carbamoylpalladium complex intermediate instead of the widely accepted palladium-hydride (Pd-H) species was the active catalytic species for this reaction.