Pattern recognition analysis of proteins using dna-decorated catalytic gold nanoparticles

Xiafeng Yang; Jiang Li; Hao Pei; Di Li; Yun Zhao; Jimin Gao; Jianxin Lu; Jiye Shi; Chunhai Fan; Qing Huang

doi:10.1002/smll.201202772

Pattern recognition analysis of proteins using dna-decorated catalytic gold nanoparticles

Xiafeng Yang, Jiang Li, Hao Pei, Di Li, Yun Zhao, Jimin Gao, Jianxin Lu, Jiye Shi, Chunhai Fan, Qing Huang

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

A label-free protein analysis strategy is based on patterns of gold nanoparticle (AuNP) growth. AuNPs pretreated with different oligonucleotides are challenged with various proteins. After Au reduction, the colorimetric patterns are processed with linear discriminant analysis. This method discriminates different proteins, or one protein of different concentrations, in mixed samples or even serum and urine.

Original language	English
Pages (from-to)	2844-2849
Number of pages	6
Journal	Small
Volume	9
Issue number	17
DOIs	https://doi.org/10.1002/smll.201202772
State	Published - 9 Sep 2013
Externally published	Yes

Keywords

biosensors
gold nanoparticles
oligonucleotides
pattern recognition
proteins

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10.1002/smll.201202772

Cite this

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abstract = "A label-free protein analysis strategy is based on patterns of gold nanoparticle (AuNP) growth. AuNPs pretreated with different oligonucleotides are challenged with various proteins. After Au reduction, the colorimetric patterns are processed with linear discriminant analysis. This method discriminates different proteins, or one protein of different concentrations, in mixed samples or even serum and urine.",

keywords = "biosensors, gold nanoparticles, oligonucleotides, pattern recognition, proteins",

author = "Xiafeng Yang and Jiang Li and Hao Pei and Di Li and Yun Zhao and Jimin Gao and Jianxin Lu and Jiye Shi and Chunhai Fan and Qing Huang",

year = "2013",

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AU - Yang, Xiafeng

AU - Li, Jiang

AU - Pei, Hao

AU - Li, Di

AU - Zhao, Yun

AU - Gao, Jimin

AU - Lu, Jianxin

AU - Shi, Jiye

AU - Fan, Chunhai

AU - Huang, Qing

PY - 2013/9/9

Y1 - 2013/9/9

N2 - A label-free protein analysis strategy is based on patterns of gold nanoparticle (AuNP) growth. AuNPs pretreated with different oligonucleotides are challenged with various proteins. After Au reduction, the colorimetric patterns are processed with linear discriminant analysis. This method discriminates different proteins, or one protein of different concentrations, in mixed samples or even serum and urine.

AB - A label-free protein analysis strategy is based on patterns of gold nanoparticle (AuNP) growth. AuNPs pretreated with different oligonucleotides are challenged with various proteins. After Au reduction, the colorimetric patterns are processed with linear discriminant analysis. This method discriminates different proteins, or one protein of different concentrations, in mixed samples or even serum and urine.

KW - biosensors

KW - gold nanoparticles

KW - oligonucleotides

KW - pattern recognition

KW - proteins

UR - https://www.scopus.com/pages/publications/84883518393

U2 - 10.1002/smll.201202772

DO - 10.1002/smll.201202772

M3 - 文章

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AN - SCOPUS:84883518393

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VL - 9

SP - 2844

EP - 2849

JO - Small

JF - Small

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ER -

Pattern recognition analysis of proteins using dna-decorated catalytic gold nanoparticles

Abstract

Keywords

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