Palladium-catalyzed oxidative cycloaddition through C-H/N-H activation: Access to benzazepines

Lei Wang; Jiayao Huang; Shiyong Peng; Hui Liu; Xuefeng Jiang; Jian Wang

doi:10.1002/anie.201208076

Palladium-catalyzed oxidative cycloaddition through C-H/N-H activation: Access to benzazepines

Lei Wang
, Jiayao Huang
, Shiyong Peng
, Hui Liu
, Xuefeng Jiang^*
, Jian Wang

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

National University of Singapore
East China Normal University

Research output: Contribution to journal › Article › peer-review

130 Scopus citations

Abstract

Rings beget rings: Benzazepines, well-known structural design elements in medicinal chemistry, are readily prepared by a one-pot palladium-catalyzed oxidative cycloaddition of isatins with various alkynes.

Original language	English
Pages (from-to)	1768-1772
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	6
DOIs	https://doi.org/10.1002/anie.201208076
State	Published - 4 Feb 2013

Keywords

C-H activation
N-H activation
benzazepine
oxidative cycloaddition
palladium

Access to Document

10.1002/anie.201208076

Cite this

@article{77ae18bc2a2e4e9dbe22f9bb6b61f78d,

title = "Palladium-catalyzed oxidative cycloaddition through C-H/N-H activation: Access to benzazepines",

abstract = "Rings beget rings: Benzazepines, well-known structural design elements in medicinal chemistry, are readily prepared by a one-pot palladium-catalyzed oxidative cycloaddition of isatins with various alkynes.",

keywords = "C-H activation, N-H activation, benzazepine, oxidative cycloaddition, palladium",

author = "Lei Wang and Jiayao Huang and Shiyong Peng and Hui Liu and Xuefeng Jiang and Jian Wang",

year = "2013",

month = feb,

day = "4",

doi = "10.1002/anie.201208076",

language = "英语",

volume = "52",

pages = "1768--1772",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "6",

}

TY - JOUR

T1 - Palladium-catalyzed oxidative cycloaddition through C-H/N-H activation

T2 - Access to benzazepines

AU - Wang, Lei

AU - Huang, Jiayao

AU - Peng, Shiyong

AU - Liu, Hui

AU - Jiang, Xuefeng

AU - Wang, Jian

PY - 2013/2/4

Y1 - 2013/2/4

N2 - Rings beget rings: Benzazepines, well-known structural design elements in medicinal chemistry, are readily prepared by a one-pot palladium-catalyzed oxidative cycloaddition of isatins with various alkynes.

AB - Rings beget rings: Benzazepines, well-known structural design elements in medicinal chemistry, are readily prepared by a one-pot palladium-catalyzed oxidative cycloaddition of isatins with various alkynes.

KW - C-H activation

KW - N-H activation

KW - benzazepine

KW - oxidative cycloaddition

KW - palladium

UR - https://www.scopus.com/pages/publications/84873403413

U2 - 10.1002/anie.201208076

DO - 10.1002/anie.201208076

M3 - 文章

C2 - 23281177

AN - SCOPUS:84873403413

SN - 1433-7851

VL - 52

SP - 1768

EP - 1772

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 6

ER -

Palladium-catalyzed oxidative cycloaddition through C-H/N-H activation: Access to benzazepines

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this