Palladium-catalyzed oxidative cycloaddition through C-H/N-H activation: Access to benzazepines

Lei Wang; Jiayao Huang; Shiyong Peng; Hui Liu; Xuefeng Jiang; Jian Wang

doi:10.1002/anie.201208076

Palladium-catalyzed oxidative cycloaddition through C-H/N-H activation: Access to benzazepines

Lei Wang, Jiayao Huang, Shiyong Peng, Hui Liu, Xuefeng Jiang, Jian Wang

School of Chemistry and Molecular Engineering

Research output: Contribution to journal › Article › peer-review

126 Scopus citations

Abstract

Rings beget rings: Benzazepines, well-known structural design elements in medicinal chemistry, are readily prepared by a one-pot palladium-catalyzed oxidative cycloaddition of isatins with various alkynes.

Original language	English
Pages (from-to)	1768-1772
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	6
DOIs	https://doi.org/10.1002/anie.201208076
State	Published - 4 Feb 2013

Keywords

C-H activation
N-H activation
benzazepine
oxidative cycloaddition
palladium

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10.1002/anie.201208076

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title = "Palladium-catalyzed oxidative cycloaddition through C-H/N-H activation: Access to benzazepines",

abstract = "Rings beget rings: Benzazepines, well-known structural design elements in medicinal chemistry, are readily prepared by a one-pot palladium-catalyzed oxidative cycloaddition of isatins with various alkynes.",

keywords = "C-H activation, N-H activation, benzazepine, oxidative cycloaddition, palladium",

author = "Lei Wang and Jiayao Huang and Shiyong Peng and Hui Liu and Xuefeng Jiang and Jian Wang",

year = "2013",

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T1 - Palladium-catalyzed oxidative cycloaddition through C-H/N-H activation

T2 - Access to benzazepines

AU - Wang, Lei

AU - Huang, Jiayao

AU - Peng, Shiyong

AU - Liu, Hui

AU - Jiang, Xuefeng

AU - Wang, Jian

PY - 2013/2/4

Y1 - 2013/2/4

N2 - Rings beget rings: Benzazepines, well-known structural design elements in medicinal chemistry, are readily prepared by a one-pot palladium-catalyzed oxidative cycloaddition of isatins with various alkynes.

AB - Rings beget rings: Benzazepines, well-known structural design elements in medicinal chemistry, are readily prepared by a one-pot palladium-catalyzed oxidative cycloaddition of isatins with various alkynes.

KW - C-H activation

KW - N-H activation

KW - benzazepine

KW - oxidative cycloaddition

KW - palladium

UR - https://www.scopus.com/pages/publications/84873403413

U2 - 10.1002/anie.201208076

DO - 10.1002/anie.201208076

M3 - 文章

C2 - 23281177

AN - SCOPUS:84873403413

SN - 1433-7851

VL - 52

SP - 1768

EP - 1772

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 6

ER -

Palladium-catalyzed oxidative cycloaddition through C-H/N-H activation: Access to benzazepines

Abstract

Keywords

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