Abstract
Oxygen participates in the biological homeostasis and pathogenesis in the human body, where oxygen-functional materials play specific and indispensable roles in interacting with molecular oxygen for oxygen generation, carrying, reduction, and cellular sensing. Oxygen-related pathologies mainly originate from cellular oxygen abnormalities, which enable the biomedical application of oxygen-functional materials with promising therapeutic potential. In this review, oxygen-functional materials that can serve as the therapeutic agents in a broad range of biomedical conditions are overviewed in diverse oxygen-relevant physical-chemical processes. Based on the most recent progress on biomedical oxygen-functional materials, the rational design of various types of oxygen-functional materials with advanced and multimodal therapeutic potentials, pathological targeting capability, and satisfactory biocompatibilities are outlined. In addition, we also point out that the underlying oxygen-relevant biomedical mechanisms must be explored in more detailed to achieve convincing approaches for the possible exploration of oxygen-functional materials.
| Original language | English |
|---|---|
| Pages (from-to) | 1115-1147 |
| Number of pages | 33 |
| Journal | Matter |
| Volume | 2 |
| Issue number | 5 |
| DOIs | |
| State | Published - 6 May 2020 |
| Externally published | Yes |
Keywords
- biomedical applications
- oxygen homeostasis
- oxygen pathology
- oxygen-functional materials
- tumor therapy