Organocatalytic asymmetric synthesis of 3,3-disubstituted oxindoles featuring two heteroatoms at the C3 position

  • Feng Zhou
  • , Xing Ping Zeng
  • , Chao Wang
  • , Xiao Li Zhao
  • , Jian Zhou*
  • *Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

88 Scopus citations

Abstract

We report the first organocatalytic asymmetric synthesis of 3,3-disubstituted oxindoles featuring two heteroatoms at the C3 position. Importantly, 3-thiooxindoles and 3-alkoxyoxindoles are demonstrated to be reactive nucleophiles for the development of catalytic asymmetric reactions for the first time.

Original languageEnglish
Pages (from-to)2022-2024
Number of pages3
JournalChemical Communications
Volume49
Issue number20
DOIs
StatePublished - 12 Feb 2013

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