TY - JOUR
T1 - One-step synthesis of amino-reserved chitosan-graft-polycaprolactone as a promising substance of biomaterial
AU - Duan, Kongrong
AU - Chen, Honglin
AU - Huang, Jin
AU - Yu, Jiahui
AU - Liu, Shiyuan
AU - Wang, Daxin
AU - Li, Yaping
PY - 2010/4/12
Y1 - 2010/4/12
N2 - One-step approach was developed to synthesize amino-reserved chitosan-graft-polycaprolactone (CS-g-PCL) by grafting ε-CL oligomers onto the hydroxyl groups of CS via ring-opening polymerization by using methanesulfonic acid as solvent and catalyst. The controllable grafting content of PCL within CS-g-PCL provided the possibility to manipulate the biodegradation rate, hydrophilicity, and hence the cytotoxicity of CS-g-PCL. As a result, the specimen synthesized from the feed molar ratio of glucosamine units in CS vs. ε-CL as 1:12 showed equivalent cytotoxicity to the neat CS and PCL against KB cell line, and the cell viability was almost close to 100%. In addition, CS-g-PCL exhibited good solubility in organic solvents, facilitating formation of PCL/CS-g-PCL blend nanofibers via electrospinning with the use of DMF/CHCl3 as solvent. Owing to the enhanced cellular attachment results from cationic amino groups, it is promising that these copolymers are ideal substances for developing drug carriers and tissue engineering scaffolds.
AB - One-step approach was developed to synthesize amino-reserved chitosan-graft-polycaprolactone (CS-g-PCL) by grafting ε-CL oligomers onto the hydroxyl groups of CS via ring-opening polymerization by using methanesulfonic acid as solvent and catalyst. The controllable grafting content of PCL within CS-g-PCL provided the possibility to manipulate the biodegradation rate, hydrophilicity, and hence the cytotoxicity of CS-g-PCL. As a result, the specimen synthesized from the feed molar ratio of glucosamine units in CS vs. ε-CL as 1:12 showed equivalent cytotoxicity to the neat CS and PCL against KB cell line, and the cell viability was almost close to 100%. In addition, CS-g-PCL exhibited good solubility in organic solvents, facilitating formation of PCL/CS-g-PCL blend nanofibers via electrospinning with the use of DMF/CHCl3 as solvent. Owing to the enhanced cellular attachment results from cationic amino groups, it is promising that these copolymers are ideal substances for developing drug carriers and tissue engineering scaffolds.
KW - Biomaterials
KW - Brush-like polycations
KW - Chitosan-graft-polycaprolactone
KW - Methanesulfonic acid
KW - One-step synthesis
UR - https://www.scopus.com/pages/publications/77249110237
U2 - 10.1016/j.carbpol.2009.12.013
DO - 10.1016/j.carbpol.2009.12.013
M3 - 文章
AN - SCOPUS:77249110237
SN - 0144-8617
VL - 80
SP - 498
EP - 503
JO - Carbohydrate Polymers
JF - Carbohydrate Polymers
IS - 2
ER -